ZFIN ID: ZDB-GENE-030131-5552
Gene Name: eukaryotic translation initiation factor 2, subunit 3 gamma
Gene Symbol: eif2s3    Nomenclature History

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Previous Names: eukaryotic translation initiation factor 2 gamma (1), fi03g03, wu:fi03g03, wu:fi37d04, zgc:63805

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have translation initiation factor activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to localize to cytosol and eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma).
Genome Resources: Alliance (1),  Gene:327341 (1),  Ensembl(GRCz11):ENSDARG00000008292 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63805]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi929Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi969Tg Transgenic Insertion 5' UTR Unknown DNA
    hi3689Tg Transgenic Insertion Intron 1 Unknown DNA
    la028599Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH eif2s3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    MEHMO syndrome Alliance MEHMO syndrome 300148
    DISEASE ASSOCIATED WITH eif2s3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process translation (more)
    Cellular Component eukaryotic translation initiation factor 2 complex (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif2s3-201 (1)    Ensembl 2112
    eif2s3-202 (1)    Ensembl 839
    eif2s3-203 (1)    Ensembl 884
    ncRNA eif2s3-004 (1) 274
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif2s3 No data available
    MARKER RELATIONSHIPS
    eif2s3 Contained in: [BAC] DKEY-30N5 (1) (order this)
    eif2s3 Encodes: [EST] fi03g03, fi37d04 (1)
    [cDNA] MGC:63805 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212711 (1) 2015 nt
    Genomic GenBank:BX469922 (1) 200409 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QGW6 (1) 472 aa
    Sequence Information (all 18)
    ORTHOLOGY for eif2s3 ( Chr: 24 )
    CITATIONS (33)