ZFIN ID: ZDB-GENE-030131-5531
Gene Name: coagulation factor V
Gene Symbol: f5    Nomenclature History

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Previous Names: si:bz20i5.3, wu:fd21h06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have copper ion binding activity. Involved in hemostasis and response to bacterium. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V).
Genome Resources: Alliance (1),  Gene:327320 (1),  Ensembl(GRCz11):ENSDARG00000055705 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 7 figures (7 images) from Thisse et al., 2005 [eu2423]
Wild-type Stages, Structures: Pharyngula:High-pec (42.0h-48.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi4006 Small Deletion Unknown Unknown CRISPR
sa2508 Point Mutation Unknown Premature Stop ENU
sa7198 Point Mutation Unknown Premature Stop ENU
sa13037 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13402 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13751 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21530 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21531 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41467 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-f5 1
    PHENOTYPE
    Data: Fig. 2 from Weyand et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH f5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Budd-Chiari syndrome Alliance {Budd-Chiari syndrome} 600880
    cerebral infarction Alliance {Stroke, ischemic, susceptibility to} 601367
    factor V deficiency Alliance Factor V deficiency 227400
    thrombophilia due to activated protein C resistance Alliance Thrombophilia due to activated protein C resistance 188055
    {Thrombophilia, susceptibility to, due to factor V Leiden} 188055
    {Pregnancy loss, recurrent, susceptibility to, 1} 614389
    DISEASE ASSOCIATED WITH f5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to bacterium (more)
    Molecular Function copper ion binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA f5-201 (1)    Ensembl 6438
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM f5 No data available
    MARKER RELATIONSHIPS
    f5 Contained in: [BAC] RP71-20I5
    f5 Encodes: [EST] eu2423 (1), fd21h06
    [cDNA] MGC:198429 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007208 (1) 6438 nt
    Genomic GenBank:AL590146 (1) 121086 nt
    Select Tool
    Polypeptide UniProtKB:Q90X47 (1) 2101 aa
    Sequence Information (all 21)
    ORTHOLOGY for f5 ( Chr: 9 )
    CITATIONS (24)