Gene
f5
- ID
- ZDB-GENE-030131-5531
- Name
- coagulation factor V
- Symbol
- f5 Nomenclature History
- Previous Names
-
- si:bz20i5.3
- wu:fd21h06
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have copper ion binding activity. Involved in hemostasis and response to bacterium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal failure; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Is expressed in liver. Orthologous to human F5 (coagulation factor V).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2423 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Weyand et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Budd-Chiari syndrome | Alliance | {Budd-Chiari syndrome} | 600880 |
| cerebral infarction | Alliance | {Stroke, ischemic, susceptibility to} | 601367 |
| factor V deficiency | Alliance | Factor V deficiency | 227400 |
| thrombophilia due to activated protein C resistance | Alliance | Thrombophilia 2 due to activated protein C resistance | 188055 |
| thrombophilia due to activated protein C resistance | Alliance | {Thrombophilia, susceptibility to, due to factor V Leiden} | 188055 |
| {Pregnancy loss, recurrent, susceptibility to, 1} | 614389 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR033138 | Multicopper oxidases, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8 C-terminal domain |
| Domain | IPR011706 | Multicopper oxidase, C-terminal |
| Domain | IPR011707 | Multicopper oxidase-like, N-terminal |
| Family | IPR024715 | Coagulation factor 5/8-like |
| Homologous_superfamily | IPR008972 | Cupredoxin |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8 C-terminal domain | Coagulation factor 5/8-like | Cupredoxin | Galactose-binding-like domain superfamily | Multicopper oxidase, C-terminal | Multicopper oxidase-like, N-terminal | Multicopper oxidases, conserved site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B7ZVT7
|
2087 |
Interactions and Pathways
No data available
Plasmids
No data available