Gene

f5

ID
ZDB-GENE-030131-5531
Name
coagulation factor V
Symbol
f5 Nomenclature History
Previous Names
  • si:bz20i5.3
  • wu:fd21h06
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have copper ion binding activity. Involved in hemostasis and response to bacterium. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); end stage renal disease; factor V deficiency; liver disease (multiple); and non-arteritic anterior ischemic optic neuropathy. Orthologous to human F5 (coagulation factor V).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Weyand et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With f5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Budd-Chiari syndrome Alliance {Budd-Chiari syndrome} 600880
cerebral infarction Alliance {Stroke, ischemic, susceptibility to} 601367
factor V deficiency Alliance Factor V deficiency 227400
thrombophilia due to activated protein C resistance Alliance Thrombophilia due to activated protein C resistance 188055
thrombophilia due to activated protein C resistance Alliance {Thrombophilia, susceptibility to, due to factor V Leiden} 188055
{Pregnancy loss, recurrent, susceptibility to, 1} 614389
Associated With f5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR033138 Multicopper oxidases, conserved site
Domain IPR000421 Coagulation factor 5/8 C-terminal domain
Domain IPR011707 Multicopper oxidase, type 3
Family IPR024715 Coagulation factor 5/8-like
Homologous_superfamily IPR008972 Cupredoxin
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Domain Details Per Protein
Protein Length Coagulation factor 5/8 C-terminal domain Coagulation factor 5/8-like Cupredoxin Galactose-binding-like domain superfamily Multicopper oxidases, conserved site Multicopper oxidase, type 3
UniProtKB:Q8AYE0 407
UniProtKB:Q32PR1 709
UniProtKB:Q90X47 2101
UniProtKB:B7ZVT7 2087
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations