Gene

cbx2

ID
ZDB-GENE-030131-5502
Name
chromobox homolog 2 (Drosophila Pc class)
Symbol
cbx2 Nomenclature History
Previous Names
  • pc1 (1)
  • wu:fd20e09
  • zgc:103563
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have methylated histone binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to localize to PRC1 complex and heterochromatin. Is expressed in several structures, including digestive system; heart; nervous system; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 46,XY sex reversal 5. Orthologous to human CBX2 (chromobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cbx2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
46,XY sex reversal 5 Alliance ?46XY sex reversal 5 613080
Associated With cbx2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023779 Chromo domain, conserved site
Conserved_site IPR033773 CBX family C-terminal motif
Domain IPR000953 Chromo/chromo shadow domain
Domain IPR023780 Chromo domain
Family IPR042796 Chromobox protein homolog 2
Homologous_superfamily IPR016197 Chromo-like domain superfamily
Domain Details Per Protein
Protein Length CBX family C-terminal motif Chromobox protein homolog 2 Chromo/chromo shadow domain Chromo domain Chromo domain, conserved site Chromo-like domain superfamily
UniProtKB:Q8JIQ9 510
UniProtKB:F1Q982 514
UniProtKB:Q5U3G5 510
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations