ZFIN ID: ZDB-GENE-030131-5391
Gene Name: SPG7 matrix AAA peptidase subunit, paraplegin
Gene Symbol: spg7    Nomenclature History

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Previous Names: fd15f08, wu:fd15f08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; metalloendopeptidase activity; and zinc ion binding activity. Predicted to be involved in mitochondrion organization. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).
Genome Resources: Alliance (1),  Gene:794740 (1),  Ensembl(GRCz11):ENSDARG00000068187 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH spg7 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 7 Alliance Spastic paraplegia 7, autosomal recessive 607259
DISEASE ASSOCIATED WITH spg7 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA spg7-201 (1)    Ensembl 3109
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM spg7 No data available
MARKER RELATIONSHIPS
spg7 Contained in: [BAC] CH211-89N7 (1), CH211-245P24 (1)
spg7 Encodes: [EST] fd15f08
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_001923083 (1) 3124 nt
Genomic RefSeq:NW_018395269 (1) Blast at MegaBLAST
Polypeptide UniProtKB:E7F2S4 (1) 788 aa
Sequence Information (all 17)
ORTHOLOGY for spg7 ( Chr: 7 )
CITATIONS (19)