Gene

spg7

ID
ZDB-GENE-030131-5391
Name
SPG7 matrix AAA peptidase subunit, paraplegin
Symbol
spg7 Nomenclature History
Previous Names
  • fd15f08
  • wu:fd15f08
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; metalloendopeptidase activity; and zinc ion binding activity. Predicted to be involved in mitochondrial protein processing; mitochondrion organization; and protein-containing complex assembly. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spg7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 7 Alliance Spastic paraplegia 7, autosomal recessive 607259
Associated With spg7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000642 Peptidase M41
Domain IPR003593 AAA+ ATPase domain
Domain IPR003959 ATPase, AAA-type, core
Domain IPR011546 Peptidase M41, FtsH extracellular
Domain IPR041569 AAA ATPase, AAA+ lid domain
Family IPR005936 Peptidase, FtsH
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR037219 Peptidase M41-like
Domain Details Per Protein
Protein Length AAA ATPase, AAA+ lid domain AAA+ ATPase domain ATPase, AAA-type, core Peptidase, FtsH Peptidase M41 Peptidase M41, FtsH extracellular Peptidase M41-like P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7F2S4 788
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations