spg7

ID

ZDB-GENE-030131-5391

Name

SPG7 matrix AAA peptidase subunit, paraplegin

Symbol

spg7 Nomenclature History

Previous Names

fd15f08
wu:fd15f08

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Orthologous to human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spg7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary spastic paraplegia 7	Alliance	Spastic paraplegia 7, autosomal recessive	607259

Associated With spg7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000642	Peptidase M41
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR011546	Peptidase M41, FtsH extracellular
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR005936	ATP-dependent zinc metalloprotease, FtsH
Family	IPR050928	ATP-dependent Zinc Metalloprotease
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR037219	Peptidase M41-like