ZFIN ID: ZDB-GENE-030131-5379
Gene Name: lysine (K)-specific demethylase 5Ba
Gene Symbol: kdm5ba    Nomenclature History

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Previous Names: id:ibd5050, jarid1b, jarid1ba, wu:fd15c05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have histone demethylase activity (H3-trimethyl-K4 specific). Predicted to be involved in chromatin remodeling. Predicted to localize to histone methyltransferase complex. Is expressed in neural rod; paraxial mesoderm; pronephric duct; and tail bud. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability; breast cancer; and malignant glioma. Orthologous to human KDM5B (lysine demethylase 5B).
Genome Resources: Alliance (1),  Gene:327168 (1),  Ensembl(GRCz11):ENSDARG00000057093 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 2 figures (2 images) from Kudoh et al., 2001 [ibd5050]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7348 Point Mutation Unknown Missense ENU
sa14585 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16159 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21908 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27786 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31828 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35081 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35082 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38842 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kdm5ba N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kdm5ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 65 618109
    DISEASE ASSOCIATED WITH kdm5ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromatin remodeling (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm5ba-201 (1)    Ensembl 5330
    kdm5ba-202 (1)    Ensembl 425
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm5ba No data available
    MARKER RELATIONSHIPS
    kdm5ba Contained in: [BAC] CH211-137O16 (1)
    kdm5ba Encodes: [EST] fd15c05, ibd5050 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128327 (1) 5322 nt
    Genomic GenBank:CR628365 (1) 191036 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QQ41 (1) 1478 aa
    Sequence Information (all 17)
    ORTHOLOGY for kdm5ba ( Chr: 11 )
    CITATIONS (22)