ZFIN ID: ZDB-GENE-030131-5357
Gene Name: argonaute RISC component 4
Gene Symbol: ago4    Nomenclature History

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Previous Names: Ago4 (1), eif2c4, fd14f04, wu:fd14f04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have miRNA binding activity. Predicted to be involved in miRNA mediated inhibition of translation. Predicted to localize to the P-body and RISC complex. Is expressed in several structures, including eye; fin; integument; pleuroperitoneal region; and somite. Orthologous to human AGO4 (argonaute RISC component 4).
Genome Resources: Alliance (1),  Gene:100535764 (1),  Ensembl(GRCz11):ENSDARG00000100854 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13019 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23604 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ago4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ago4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gene silencing by RNA (more)
    Cellular Component cytoplasm (more)
    Molecular Function miRNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003100 PAZ domain
    Domain IPR003165 Piwi domain
    Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
    Domain IPR014811 Argonaute, linker 1 domain
    Family IPR028604 Protein argonaute-4
    Domain IPR032472 Argonaute linker 2 domain
    Domain IPR032473 Protein argonaute, Mid domain
    Domain IPR032474 Protein argonaute, N-terminal
    Homologous_superfamily IPR036085 PAZ domain superfamily
    Homologous_superfamily IPR036397 Ribonuclease H superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ago4 No data available
    MARKER RELATIONSHIPS
    ago4 Contains: [SNP] rs3729002 (1), rs3729003 (1)
    ago4 Encodes: [EST] fd14f04
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001252559 (1) 2729 bp
    Genomic GenBank:CABZ01005377 (1) 48274 bp
    Select Tool
    Polypeptide UniProtKB:K4IAH1 (1) 863 aa
    Sequence Information (all 14)
    ORTHOLOGY for ago4 ( Chr: 19 )
    CITATIONS (20)