Gene
traf2b
- ID
- ZDB-GENE-030131-5345
- Name
- Tnf receptor-associated factor 2b
- Symbol
- traf2b Nomenclature History
- Previous Names
-
- fd14c07
- si:dkey-170o10.1 (1)
- wu:fd14c07
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable tumor necrosis factor receptor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; protein K63-linked ubiquitination; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; regulation of JNK cascade; and regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic side of plasma membrane. Orthologous to human TRAF2 (TNF receptor associated factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001293 | Zinc finger, TRAF-type |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR018957 | Zinc finger, C3HC4 RING-type |
| Domain | IPR032070 | TNF receptor-associated factor, BIRC3 binding domain |
| Domain | IPR037305 | TNF receptor-associated factor 2, MATH domain |
| Family | IPR012227 | TNF receptor-associated factor TRAF, metazoa |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Length | MATH/TRAF domain | TNF receptor-associated factor 2, MATH domain | TNF receptor-associated factor, BIRC3 binding domain | TNF receptor-associated factor TRAF, metazoa | TRAF-like | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, TRAF-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4ILY5
|
532 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
traf2b-202
(1)
|
2135 nt |
Interactions and Pathways
No data available
Plasmids
No data available