ZFIN ID: ZDB-GENE-030131-533
Gene Name: NHP2 ribonucleoprotein homolog (yeast)
Gene Symbol: nhp2    Nomenclature History

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Previous Names: nola2, wu:fb36b10, wu:fd61a03, zgc:73227

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have box H/ACA snoRNA binding activity. Predicted to be involved in nucleic acid metabolic process. Predicted to localize to box H/ACA snoRNP complex and telomerase holoenzyme complex. Is expressed in several structures, including digestive system; immature eye; midbrain; retina; and segmental plate. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein).
Genome Resources: Alliance (1),  Gene:100003787 (1),  Ensembl(GRCz11):ENSDARG00000069422 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:73227]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010961Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1137 Point Mutation Unknown Premature Stop ENU
    sa37343 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39337 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nhp2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive dyskeratosis congenita 2 Alliance Dyskeratosis congenita, autosomal recessive 2 613987
    DISEASE ASSOCIATED WITH nhp2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process rRNA pseudouridine synthesis (more)
    Cellular Component small nucleolar ribonucleoprotein complex (more)
    Molecular Function RNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nhp2-201 (1)    Ensembl 958
    ncRNA nhp2-002 (1)    Ensembl 620
    nhp2-003 (1)    Ensembl 698
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nhp2 No data available
    MARKER RELATIONSHIPS
    nhp2 Contained in: [BAC] DKEY-25L11 (1) (order this)
    nhp2 Encodes: [EST] fb36b10, fd61a03 (1)
    [cDNA] MGC:73227 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212597 (1)
    Genomic GenBank:CR749164 (1) 211000 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6PBV6 (1) 150 aa
    Sequence Information (all 17)
    ORTHOLOGY for nhp2 ( Chr: 21 )
    CITATIONS (26)