Gene

polr1a

ID
ZDB-GENE-030131-5286
Name
RNA polymerase I subunit A
Symbol
polr1a Nomenclature History
Previous Names
  • fa26a03
  • sb:cb935
  • wu:fa26a03
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in embryonic viscerocranium morphogenesis and neural crest cell development. Predicted to localize to RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin musculature; and segmental plate. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polr1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrofacial dysostosis Cincinnati type Alliance Acrofacial dysostosis, Cincinnati type 616462
Associated With polr1a Via Experimental Models
Human Disease Fish Conditions Citations
acrofacial dysostosis Cincinnati type polr1ahi3639Tg/hi3639Tg control Watt et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000722 RNA polymerase, alpha subunit
Domain IPR006592 RNA polymerase, N-terminal
Domain IPR007066 RNA polymerase Rpb1, domain 3
Domain IPR007080 RNA polymerase Rpb1, domain 1
Domain IPR007081 RNA polymerase Rpb1, domain 5
Domain IPR007083 RNA polymerase Rpb1, domain 4
Family IPR015699 DNA-directed RNA pol I, largest subunit
Homologous_superfamily IPR038120 RNA polymerase Rpb1, funnel domain superfamily
Homologous_superfamily IPR042102 RNA polymerase Rpb1, domain 3 superfamily
Domain Details Per Protein
Protein Length DNA-directed RNA pol I, largest subunit RNA polymerase, alpha subunit RNA polymerase, N-terminal RNA polymerase Rpb1, domain 1 RNA polymerase Rpb1, domain 3 RNA polymerase Rpb1, domain 3 superfamily RNA polymerase Rpb1, domain 4 RNA polymerase Rpb1, domain 5 RNA polymerase Rpb1, funnel domain superfamily
UniProtKB:A0A0R4I9V4 1693
UniProtKB:A0A0R4IPG4 1684
UniProtKB:Q7SXQ2 810
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations