ZFIN ID: ZDB-GENE-030131-5286
Gene Name: polymerase (RNA) I polypeptide A
Gene Symbol: polr1a

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Previous Names: fa26a03, sb:cb935, wu:fa26a03

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb935]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  alar plate midbrain region, brain, cerebellum, eye (all 20) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3639Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012505Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1376 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2745 Point Mutation Donor Splice Site Splice Site ENU
    sa12570 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa22458 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22459 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22460 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 9 figures from 5 publications
    Observed in: apoptotic process, blood, brain, central nervous system (all 32) expand
    DISEASE ASSOCIATED WITH polr1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    acrofacial dysostosis Cincinnati type Acrofacial dysostosis, Cincinnati type 616462
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000722 (1)
  • InterPro:IPR006592 (1)
  • InterPro:IPR007066 (1)
  • InterPro:IPR007080 (1)
  • InterPro:IPR007081 (1)
  • InterPro:IPR007083 (1)
  • InterPro:IPR015699 (1)
  • Pfam:PF00623 (1)
  • Pfam:PF04983 (1)
  • Pfam:PF04997 (1)
  • Pfam:PF04998 (1)
  • Pfam:PF05000 (1)
  • EC:2.7.7.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA polr1a-001 (1) 5286
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM polr1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    polr1aContained in: [BAC] CH73-87E17 (1) (order this), CH211-2M15 (1) (order this)
    polr1aEncodes: [EST] cb935 (1) (order this), fa26a03
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001922804 (1) 5309bp
    Genomic GenBank:AL929267 (1) 175892bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9V4 (1) 1693aa
    Sequence Clusters UniGene:12641 (1)
    Sequence Information (all 31)
    OTHER polr1a GENE PAGES
  • Gene:327078 (1)
  • VEGA:OTTDARG00000020893 (1)
  • Ensembl(GRCz10):ENSDARG00000098375 (1)
  • ORTHOLOGY for polr1a (Chr: 14)
    Species Symbol Chromosome Accession # Evidence
    Human POLR1A 2
  • Gene:25885
  • OMIM:616404
  • HGNC:17264
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Mouse Polr1a 6
  • MGI:1096397
  • Gene:20019
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (28)