ZFIN ID: ZDB-GENE-030131-5286
Gene Name: polymerase (RNA) I polypeptide A
Gene Symbol: polr1a
Previous Names: fa26a03, sb:cb935, wu:fa26a03
Location: Chr: 14   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb935]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  alar plate midbrain region, brain, cerebellum, eye (all 20) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 9 Genotypes

Allele Type Mutagen Suppliers
hi3639Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012505Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1376 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2745 Point Mutation ENU
    sa12570 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 9 figures from 5 publications
    Observed in: apoptotic process, blood, brain, central nervous system (all 32) expand
    DISEASE ASSOCIATED WITH polr1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    acrofacial dysostosis Cincinnati type Acrofacial dysostosis, Cincinnati type 616462
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000722 (1)
  • InterPro:IPR006592 (1)
  • InterPro:IPR007066 (1)
  • InterPro:IPR007080 (1)
  • InterPro:IPR007081 (1)
  • InterPro:IPR007083 (1)
  • InterPro:IPR015699 (1)
  • Pfam:PF00623 (1)
  • Pfam:PF04983 (1)
  • Pfam:PF04997 (1)
  • Pfam:PF04998 (1)
  • Pfam:PF05000 (1)
  • EC:2.7.7.6 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA polr1a-001 (1) 5286
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM polr1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    polr1a Contained in: [BAC] CH73-87E17 (1) (order this), CH211-2M15 (1) (order this)
    polr1a Encodes: [EST] cb935 (1) (order this), fa26a03
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001922804 (1) 5343 bp
    Genomic GenBank:AL929267 (1) 175892 bp
    Select Tool
    Polypeptide UniProtKB:E7F710 (1) 1710 aa
    Sequence Clusters UniGene:12641 (1)
    Sequence Information (all 31)
    OTHER polr1a GENE PAGES
  • Gene:327078 (1)
  • VEGA:OTTDARG00000020893 (1)
  • Ensembl(Zv9):ENSDARG00000029172 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish polr1a 14  
    Human POLR1A 2 (2p11.2)
  • OMIM:616404
  • Gene:25885
  • Mouse Polr1a 6 ( 32.21 cM)
  • MGI:1096397
  • Gene:20019
  • Orthology Details
    CITATIONS (28)