Gene
wee1
- ID
- ZDB-GENE-030131-5268
- Name
- WEE1 G2 checkpoint kinase
- Symbol
- wee1 Nomenclature History
- Previous Names
-
- fa20h03
- wu:fa20h03
- zgc:136514
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine kinase activity. Acts upstream of or within response to light stimulus. Predicted to be active in cytoplasm and nucleus. Orthologous to human WEE1 (WEE1 G2 checkpoint kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR017164 | Wee1-like protein kinase |
| Family | IPR050339 | Cell Cycle and Stress Response Kinase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cell Cycle and Stress Response Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Wee1-like protein kinase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LYE1 | InterPro | |||||||
| UniProtKB:Q6DRI0 | InterPro | 612 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-8L13 | ZFIN Curated Data | |
| Encodes | EST | fa20h03 | ||
| Encodes | cDNA | MGC:136514 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309435 (1) | 2947 nt | ||
| Genomic | GenBank:BX323598 (1) | 197329 nt | ||
| Polypeptide | UniProtKB:Q6DRI0 (1) | 612 aa |
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Chen, F., Huang, D., Shi, H., Gao, C., Wang, Y., Peng, J. (2020) Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy. Cell regeneration (London, England). 9:8
- Akle, V., Stankiewicz, A.J., Kharchenko, V., Yu, L., Kharchenko, P.V., Zhdanova, I.V. (2017) Circadian Kinetics of Cell Cycle Progression in Adult Neurogenic Niches of a Diurnal Vertebrate. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(7):1900-1909
- Xue, Y., Gao, S., Liu, F. (2015) Genome-wide Analysis of the Zebrafish Klf Family Identifies Two Genes important for Erythroid Maturation. Developmental Biology. 403(2):115-27
- Takahashi, K., Kotani, T., Katsu, Y., Yamashita, M. (2014) Possible involvement of insulin-like growth factor 2 mRNA-binding protein 3 in zebrafish oocyte maturation as a novel cyclin B1 mRNA-binding protein that represses the translation in immature oocytes. Biochemical and Biophysical Research Communications. 448(1):22-7
- Peyric, E., Moore, H.A., and Whitmore, D. (2013) Circadian clock regulation of the cell cycle in the zebrafish intestine. PLoS One. 8(8):e73209
- Idda, M.L., Kage, E., Lopez-Olmedam, J.F., Mracek, P., Foulkes, N.S., and Vallone, D. (2012) Circadian timing of injury-induced cell proliferation in zebrafish. PLoS One. 7(3):e34203
- Tamai, T.K., Young, L.C., Cox, C.A., and Whitmore, D. (2012) Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation. Journal of biological rhythms. 27(3):226-236
- Ye, Q., Chen, D., Xi, Y., Li, J., Shao, J., and Li, L. (2012) Effects of light illumination and the expression of wee1 on tissue regeneration in adult zebrafish. Biochemical and Biophysical Research Communications. 428(1):132-136
- Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32
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