ZFIN ID: ZDB-GENE-030131-5143
Gene Name: PRP4 pre-mRNA processing factor 4 homolog (yeast)
Gene Symbol: prpf4    Nomenclature History

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Previous Names: mg:ab03a02, zgc:65943

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have U4 snRNA binding activity and U6 snRNA binding activity. Involved in chordate embryonic development; mRNA splicing, via spliceosome; and sensory system development. Predicted to localize to U4/U6 x U5 tri-snRNP complex. Is expressed in brain; eye; posterior lateral line primordium; and spinal cord. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA processing factor 4).
Genome Resources: Alliance (1),  Gene:326944 (1),  Ensembl(GRCz11):ENSDARG00000067639 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65943]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33729 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tsu5is Insertion Exon 3 Unknown CRISPR
    tsu243Tg Transgenic Insertion Unknown Unknown DNA
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prpf4 1
    MO1-prpf4 N/A 3
    DISEASE ASSOCIATED WITH prpf4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 70 Alliance Retinitis pigmentosa 70 615922
    DISEASE ASSOCIATED WITH prpf4 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    retinitis pigmentosa WT + MO1-prpf4 standard conditions Linder et al., 2011
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component nuclear speck (more)
    Molecular Function U4 snRNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prpf4-201 (1)    Ensembl 1812
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prpf4 No data available
    MARKER RELATIONSHIPS
    prpf4 Contained in: [BAC] CH211-69I3 (1), CH211-202F5 (1)
    prpf4 Contains: [SNP] rs3727904 (1), rs3727905 (1), rs3727906 (1), rs3727907 (1)
    prpf4 Encodes: [EST] ab03a02
    [cDNA] MGC:65943 (1), MGC:174498 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199755 (1) 1820 nt
    Genomic GenBank:CR925761 (1) 97258 nt
    Select Tool
    Polypeptide UniProtKB:Q6PH45 (1) 507 aa
    Sequence Information (all 16)
    ORTHOLOGY for prpf4 ( Chr: 5 )
    CITATIONS (27)