Gene

prpf4

ID
ZDB-GENE-030131-5143
Name
PRP4 pre-mRNA processing factor 4 homolog (yeast)
Symbol
prpf4 Nomenclature History
Previous Names
  • mg:ab03a02
  • zgc:65943
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have U4 snRNA binding activity and U6 snRNA binding activity. Involved in chordate embryonic development; mRNA splicing, via spliceosome; and sensory system development. Predicted to localize to U4/U6 x U5 tri-snRNP complex. Is expressed in brain; eye; posterior lateral line primordium; and spinal cord. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA processing factor 4).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prpf4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 70 Alliance Retinitis pigmentosa 70 615922
Associated With prpf4 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR014906 Pre-mRNA processing factor 4 (PRP4)-like
Domain IPR017986 WD40-repeat-containing domain
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036285 PRP4-like superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length G-protein beta WD-40 repeat Pre-mRNA processing factor 4 (PRP4)-like PRP4-like superfamily WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6PH45 507
UniProtKB:A0A2R8QIJ4 449
UniProtKB:A0A2R8PY92 278
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations