ZFIN ID: ZDB-GENE-030131-5128
Gene Name: eukaryotic translation elongation factor 2b
Gene Symbol: eef2b    Nomenclature History

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Previous Names: eef2l, EF-2 (1), fe49h02, wu:fe49h02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have GTPase activity; ribosome binding activity; and translation elongation factor activity. Involved in cellular response to xenobiotic stimulus and chordate embryonic development. Predicted to localize to cytosol and ribonucleoprotein complex. Is expressed in several structures, including epidermis; immature eye; nervous system; tail bud; and trunk. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2).
Genome Resources: Alliance (1),  Gene:326929 (1),  Ensembl(GRCz11):ENSDARG00000100371 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19909 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-eef2b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eef2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spinocerebellar ataxia type 26 Alliance ?Spinocerebellar ataxia 26 609306
    DISEASE ASSOCIATED WITH eef2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to xenobiotic stimulus (more)
    Cellular Component ribonucleoprotein complex (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eef2b-201 (1)    Ensembl 2845
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eef2b No data available
    MARKER RELATIONSHIPS
    eef2b Contained in: [BAC] CH73-250D7 (1)
    eef2b Encodes: [EST] cegs191 (1) (order this), fe49h02, IMAGE:6895891 (1), IMAGE:6902416 (1)
    [cDNA] MGC:55904 (1), MGC:77674 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200458 (1) 2826 nt
    Genomic GenBank:CU651576 (1) 90414 nt
    Select Tool
    Polypeptide UniProtKB:A0A286Y8X9 (1) 860 aa
    Sequence Information (all 21)
    ORTHOLOGY for eef2b ( Chr: 2 )
    CITATIONS (28)