Gene

myo1ea

ID
ZDB-GENE-030131-5127
Name
myosin IEa
Symbol
myo1ea Nomenclature History
Previous Names
  • myo1e1 (1)
  • myo1e
  • wu:fc15g04
  • wu:fe49h01
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in somite 2 and somite 3. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Sittaramane et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myo1ea Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
focal segmental glomerulosclerosis 6 Alliance Glomerulosclerosis, focal segmental, 6 614131
Associated With myo1ea Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001452 SH3 domain
Domain IPR001609 Myosin head, motor domain
Domain IPR010926 Class I myosin tail homology domain
Domain IPR035507 Unconventional myosin-Ie/If, SH3 domain
Domain IPR036072 Class I myosin, motor domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Class I myosin, motor domain Class I myosin tail homology domain IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain P-loop containing nucleoside triphosphate hydrolase SH3 domain SH3-like domain superfamily Unconventional myosin-Ie/If, SH3 domain
UniProtKB:E7FDV0 1117
UniProtKB:A0A2R8RZ88 88
UniProtKB:A0A2R8QQJ0 981
UniProtKB:A0A1D5NS66 193
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations