ZFIN ID: ZDB-GENE-030131-5127
Gene Name: myosin IEa
Gene Symbol: myo1ea    Nomenclature History

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Previous Names: myo1e1 (1), myo1e, wu:fc15g04, wu:fe49h01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin binding activity; and motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Is expressed in somite 2 and somite 3. Orthologous to human MYO1E (myosin IE).
Genome Resources: Alliance (1),  Gene:555285 (1),  Ensembl(GRCz11):ENSDARG00000036179 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Sittaramane et al., 2008
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20979 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20980 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26972 Point Mutation Unknown Premature Stop ENU
    sa30634 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40918 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40919 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myo1ea N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myo1ea HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 6 Alliance Glomerulosclerosis, focal segmental, 6 614131
    DISEASE ASSOCIATED WITH myo1ea VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glomerular filtration (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001452 SH3 domain
    Domain IPR001609 Myosin head, motor domain
    Domain IPR010926 Class I myosin tail homology domain
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Domain IPR035507 Unconventional myosin-Ie/If, SH3 domain
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Domain IPR036072 Class I myosin, motor domain
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo1ea-201 (1)    Ensembl 4565
    myo1ea-202 (1)    Ensembl 817
    ncRNA myo1ea-002 (1)    Ensembl 612
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo1ea No data available
    MARKER RELATIONSHIPS
    myo1ea Contained in: [BAC] CH211-108M10 (1), CH211-214O7 (1), CH211-280N5 (1)
    myo1ea Contains: [SNP] rs3728076 (1), rs3728077 (1)
    myo1ea Encodes: [EST] fc15g04 (1), fe49h01
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005168926 (1) 4586 bp
    Genomic GenBank:BX663518 (1) 200579 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7FDV0 (1) 1117 aa
    Sequence Information (all 24)
    ORTHOLOGY for myo1ea ( Chr: 7 )
    CITATIONS (23)