Gene
myo1ea
- ID
- ZDB-GENE-030131-5127
- Name
- myosin IEa
- Symbol
- myo1ea Nomenclature History
- Previous Names
-
- myo1e1 (1)
- myo1e
- wu:fc15g04
- wu:fe49h01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in somite 2 and somite 3. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE).
- Genome Resources
- Note
- None
- All Expression Data
- 1 figure from Sittaramane et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 6 | Alliance | Glomerulosclerosis, focal segmental, 6 | 614131 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001609 | Myosin head, motor domain |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR035507 | Unconventional myosin-Ie/If, SH3 domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class I myosin, motor domain | Class I myosin tail homology domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Unconventional myosin-Ie/If, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FDV0
|
1117 | |||||||||
|
UniProtKB:A0A2R8RZ88
|
88 | |||||||||
|
UniProtKB:A0A2R8QQJ0
|
981 | |||||||||
|
UniProtKB:A0A1D5NS66
|
193 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
myo1ea-201
(1)
|
4565 nt | |
| mRNA |
myo1ea-202
(1)
|
817 nt | |
| ncRNA |
myo1ea-002
(1)
|
612 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl