ZFIN Gene: myo1ea

ZFIN ID: ZDB-GENE-030131-5127

ZFIN ID: ZDB-GENE-030131-5127

Gene Name:

myosin IEa

Gene Symbol:

myo1ea Nomenclature History

Previous Names:

myo1e1 (1), myo1e, wu:fc15g04, wu:fe49h01

Gene Type:

protein_coding_gene

Location:

Chr: 7 Mapping Details/Browsers

Description:

Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to several cellular components, including actin cytoskeleton; actin-based cell projection; and vesicle. Is expressed in somite 2 and somite 3. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE).

Genome Resources:

Alliance (1), Gene:555285 (1), Ensembl(GRCz11):ENSDARG00000036179 (2)

GENE EXPRESSION
All Expression Data:	Fig. 3 from Sittaramane et al., 2008
Wild-type Stages, Structures:	Pharyngula:Prim-25 (36.0h-42.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
	somite 2 somite 3
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa20979	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20980	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa26972	Point Mutation	Unknown	Premature Stop	ENU
sa30634	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40918	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40919	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-myo1ea	N/A	1

PHENOTYPE No data available

DISEASE ASSOCIATED WITH myo1ea HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
focal segmental glomerulosclerosis 6	Alliance	Glomerulosclerosis, focal segmental, 6	614131

DISEASE ASSOCIATED WITH myo1ea VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	glomerular filtration (more)
Cellular Component	myosin complex (more)
Molecular Function	actin binding (more)

GO Terms (all 18)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	myo1ea-201 (1)	4565	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	myo1ea-202 (1)	817	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	myo1ea-002 (1)	612	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM myo1ea No data available

MARKER RELATIONSHIPS

myo1ea Contained in:	[BAC] CH211-108M10 (1), CH211-214O7 (1), CH211-280N5 (1)
myo1ea Contains:	[SNP] rs3728076 (1), rs3728077 (1)
myo1ea Encodes:	[EST] fc15g04 (1), fe49h01

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005168926 (1)	4586 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX663518 (1)	200579 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:E7FDV0 (1)	1117 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 24)

ORTHOLOGY for myo1ea ( Chr: 7 )

CITATIONS (24)

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