ZFIN ID: ZDB-GENE-030131-5127
Gene Name: myosin IEa
Gene Symbol: myo1ea    Nomenclature History

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Previous Names: myo1e1 (1), myo1e, wu:fc15g04, wu:fe49h01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to several cellular components, including actin cytoskeleton; actin-based cell projection; and vesicle. Is expressed in somite 2 and somite 3. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE).
Genome Resources: Alliance (1),  Gene:555285 (1),  Ensembl(GRCz11):ENSDARG00000036179 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Sittaramane et al., 2008
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20979 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20980 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26972 Point Mutation Unknown Premature Stop ENU
    sa30634 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40918 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40919 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myo1ea N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myo1ea HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 6 Alliance Glomerulosclerosis, focal segmental, 6 614131
    DISEASE ASSOCIATED WITH myo1ea VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glomerular filtration (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo1ea-201 (1)    Ensembl 4565
    myo1ea-202 (1)    Ensembl 817
    ncRNA myo1ea-002 (1)    Ensembl 612
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo1ea No data available
    MARKER RELATIONSHIPS
    myo1ea Contained in: [BAC] CH211-108M10 (1), CH211-214O7 (1), CH211-280N5 (1)
    myo1ea Contains: [SNP] rs3728076 (1), rs3728077 (1)
    myo1ea Encodes: [EST] fc15g04 (1), fe49h01
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005168926 (1) 4586 nt
    Genomic GenBank:BX663518 (1) 200579 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7FDV0 (1) 1117 aa
    Sequence Information (all 24)
    ORTHOLOGY for myo1ea ( Chr: 7 )
    CITATIONS (24)