Gene
myo1ea
- ID
- ZDB-GENE-030131-5127
- Name
- myosin IEa
- Symbol
- myo1ea Nomenclature History
- Previous Names
-
- myo1e1 (1)
- myo1e
- wu:fc15g04
- wu:fe49h01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within glomerular filtration and glomerulus development. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. Is expressed in somite 2 and somite 3. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sittaramane et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 6 | Alliance | Glomerulosclerosis, focal segmental, 6 | 614131 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001609 | Myosin head, motor domain |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR035507 | Unconventional myosin-Ie/If, SH3 domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class I myosin, motor domain | Class I myosin tail homology domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Unconventional myosin-Ie/If, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TD18
|
1106 | |||||||||
|
UniProtKB:A0A8M2BG81
|
1116 | |||||||||
|
UniProtKB:E7FDV0
|
1117 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
myo1ea-201
(1)
|
4565 nt | |
| mRNA |
myo1ea-202
(1)
|
817 nt | |
| ncRNA |
myo1ea-002
(1)
|
612 nt |
Interactions and Pathways
No data available
Plasmids
No data available