ZFIN ID: ZDB-GENE-030131-512
Gene Name: adenylate kinase 2
Gene Symbol: ak2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fb34f05, wu:fj80e03

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have adenylate kinase activity. Involved in hematopoietic stem cell differentiation and leukocyte differentiation. Predicted to localize to mitochondrion. Is expressed in head; hematopoietic system; and intermediate cell mass of mesoderm. Used to study reticular dysgenesis. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2).
Genome Resources: Alliance (1),  Gene:321793 (1),  Ensembl(GRCz11):ENSDARG00000005926 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63946]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg14 Small Deletion Exon 1 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
hg15 Insertion Exon 1 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
hg16 Point Mutation Exon 4 Missense ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ak2 N/A 2
MO2-ak2 N/A 1
DISEASE ASSOCIATED WITH ak2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
reticular dysgenesis Alliance Reticular dysgenesis 267500
DISEASE ASSOCIATED WITH ak2 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
reticular dysgenesis ak2hg16/hg16 control Rissone et al., 2015
ak2hg14/hg14 control Rissone et al., 2015
GENE ONTOLOGY
Ontology GO Term
Biological Process hematopoietic progenitor cell differentiation (more)
Cellular Component mitochondrial intermembrane space (more)
Molecular Function adenylate kinase activity (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ak2-201 (1)    Ensembl 1478
ncRNA ak2-002 (1)    Ensembl 680
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ak2 No data available
MARKER RELATIONSHIPS
ak2 Contained in: [BAC] CH211-197N10 (1), DKEYP-116A7 (1)
ak2 Encodes: [EST] fb34f05, fj80e03 (1)
[cDNA] MGC:63946 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212596 (1) 1458 nt
Genomic GenBank:BX957241 (1) 199001 nt
Select Tool
Polypeptide UniProtKB:Q1L8L9 (1) 241 aa
Sequence Information (all 19)
ORTHOLOGY for ak2 ( Chr: 19 )
CITATIONS (34)