ZFIN ID: ZDB-GENE-030131-490
Gene Name: LEM domain containing 3
Gene Symbol: lemd3
Sequence Ontology ID : SO:0000704

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Previous Names: im:7158446, si:dkey-6a5.6, wu:fb34b12

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(Including Attributions)
Location: Chr: 4 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have nucleic acid binding activity; predicted to be involved in negative regulation of BMP signaling pathway and nuclear envelope organization; predicted to localize to the integral  ...
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7158446]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31386 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40250 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 2 figures from Wang et al., 2018
    Observed in:
    DISEASE ASSOCIATED WITH lemd3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Osteopoikilosis with or without melorheostosis 166700
    Buschke-Ollendorff syndrome 166700
    DISEASE ASSOCIATED WITH lemd3 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    arteriovenous malformations of the brain pku6Tg + MO2-lemd3 standard conditions Wang et al., 2018
    pku6Tg + MO1-lemd3 standard conditions Wang et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cerebellum vasculature development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003887 (1)
  • InterPro:IPR011015 (1)
  • InterPro:IPR012677 (1)
  • InterPro:IPR018996 (1)
  • InterPro:IPR034394 (1)
  • InterPro:IPR034997 (1)
  • InterPro:IPR035979 (1)
  • PROSITE:PS50954 (1)
  • Pfam:PF03020 (1)
  • Pfam:PF09402 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lemd3-201 (1) 2988
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM lemd3 No data available
    MARKER RELATIONSHIPS
    lemd3Contained in: [BAC] DKEY-6A5 (1) (order this)
    lemd3Encodes: [EST] fb34b12, IMAGE:7158446 (1) (order this)
    [cDNA] MGC:174981 (1) (order this), MGC:194587 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044864 (1) 2918bp
    Genomic GenBank:BX119963 (1) 229125bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5TZH9 (1) 841aa
    Sequence Clusters UniGene:106184 (1)
    Sequence Information (all 23)
    OTHER lemd3 GENE PAGES
  • Alliance (1)
  • Gene:558474 (1)
  • VEGA:OTTDARG00000007868 (1)
  • Ensembl(GRCz11):ENSDARG00000015824 (2)
  • ORTHOLOGY for lemd3 (Chr: 4)
    CITATIONS (21)