ZFIN ID: ZDB-GENE-030131-4827
Gene Name: hedgehog interacting protein
Gene Symbol: hhip    Nomenclature History

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Previous Names: Hip (1), fd99f01, uki, ukkie, wu:fc52e12, wu:fd99f01, zgc:153478

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have catalytic activity. Involved in fin development; negative regulation of muscle organ development; and negative regulation of smoothened signaling pathway. Localizes to intrinsic component of plasma membrane. Is expressed in several structures, including axis; mesoderm; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein).
Genome Resources: Alliance (1),  Gene:326102 (1),  Ensembl(GRCz11):ENSDARG00000060397 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu418b Point Mutation Exon 5 Premature Stop ENU
hu540a Point Mutation Exon 5 Premature Stop ENU
sa19529 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32711 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39643 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc256d Point Mutation Exon 7 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko666a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hhip 1
    MO1-hhip N/A 1
    MO2-hhip N/A 2
    MO3-hhip N/A 1
    DISEASE ASSOCIATED WITH hhip HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hhip VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of muscle organ development (more)
    Cellular Component intrinsic component of plasma membrane (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hhip-201 (1)    Ensembl 4575
    ncRNA hhip-002 (1)    Ensembl 731
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hhip No data available
    MARKER RELATIONSHIPS
    hhip Contained in: [BAC] CH211-194G2 (1)
    hhip Contains: [SNP] rs3727539 (1)
    hhip Encodes: [EST] fc52e12, fd99f01
    [cDNA] MGC:153478 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080012 (1) 4587 nt
    Genomic GenBank:BX276105 (1) 209486 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0B5JK82 (1) 693 aa
    Sequence Information (all 20)
    ORTHOLOGY for hhip ( Chr: 1 )
    CITATIONS (52)