Gene
rasa1a
- ID
- ZDB-GENE-030131-4694
- Name
- RAS p21 protein activator (GTPase activating protein) 1a
- Symbol
- rasa1a Nomenclature History
- Previous Names
-
- rasa1
- fd52c05
- si:dkey-195m1.3
- wu:fd52c05
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within blood vessel development and ephrin receptor signaling pathway. Is expressed in head. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kawasaki et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca35 | Allele with one insertion | Exon 2 | Unknown | CRISPR | |
| sa9711 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10485 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15062 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15906 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20521 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33700 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023152 | Ras GTPase-activating protein, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR001936 | Ras GTPase-activating domain |
| Domain | IPR035652 | RasGAP, SH3 domain |
| Domain | IPR035841 | Ras GTPase-activating protein 1, N-terminal SH2 domain |
| Domain | IPR035842 | Ras GTPase-activating protein 1, C-terminal SH2 domain |
| Family | IPR039360 | Ras GTPase-activating protein |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | RasGAP, SH3 domain | Ras GTPase-activating domain | Ras GTPase-activating protein | Ras GTPase-activating protein 1, C-terminal SH2 domain | Ras GTPase-activating protein 1, N-terminal SH2 domain | Ras GTPase-activating protein, conserved site | Rho GTPase activation protein | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q9R0 | InterPro | 892 | |||||||||||||||
| UniProtKB:F1R3X3 | InterPro | 1010 | |||||||||||||||
| UniProtKB:A0AB32TRS2 | InterPro | 995 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rasa1a-201
(1)
|
Ensembl | 3,033 nt | ||
| mRNA |
rasa1a-202
(1)
|
Ensembl | 4,309 nt | ||
| mRNA |
rasa1a-203
(1)
|
Ensembl | 578 nt | ||
| ncRNA |
rasa1a-003
(1)
|
Ensembl | 667 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-282C7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-195M1 | ZFIN Curated Data | |
| Encodes | EST | fd52c05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221515 (1) | 4472 nt | ||
| Genomic | GenBank:BX470189 (1) | 183070 nt | ||
| Polypeptide | UniProtKB:F1R3X3 (1) | 1010 aa |
- Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):
- Shin, M., Yin, H.M., Shih, Y.H., Nozaki, T., Portman, D., Toles, B., Kolb, A., Luk, K., Isogai, S., Ishida, K., Hanasaka, T., Parsons, M.J., Wolfe, S.A., Burns, C.E., Burns, C.G., Lawson, N.D. (2023) Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish. Developmental Cell. 58(22):2614-2626.e7
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Roberto, V.P., Tiago, D.M., Gautvik, K., Cancela, M.L. (2015) Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Gene. 566(1):54-62
- Kawasaki, J., Aegerter, S., Fevurly, R.D., Mammoto, A., Mammoto, T., Sahin, M., Mably, J.D., Fishman, S.J., Chan, J. (2014) RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J. Clin. Invest.. 124(6):2774-84
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