ZFIN ID: ZDB-GENE-030131-4663
Gene Name: plexin A4
Gene Symbol: plxna4    Nomenclature History

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Previous Names: wu:fd49b01, wu:fe15f03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have semaphorin receptor activity. Involved in axon guidance; axonal defasciculation; and morphogenesis of a branching structure. Predicted to localize to integral component of plasma membrane and semaphorin receptor complex. Is expressed in several structures, including basal plate midbrain region; nervous system; optic vesicle; presumptive neural retina; and trigeminal placode. Orthologous to human PLXNA4 (plexin A4).
Genome Resources: Alliance (1),  Gene:325938 (1),  Ensembl(GRCz11):ENSDARG00000019328 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024435Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024437Tg Transgenic Insertion Unknown Unknown DNA
    la024438Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028976Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028977Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-plxna4
    1
    CRISPR2-plxna4
    1
    MO1-plxna4 N/A 3
    PHENOTYPE
    Data: Fig. S3 from van der Klaauw et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH plxna4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH plxna4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonal defasciculation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function semaphorin receptor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plxna4-201 (1)    Ensembl 8676
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plxna4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(isl1-hsp70l:dnplxna4-GFP) hsp70lisl1 GFPplxna4 Danio rerio 3 5
    MARKER RELATIONSHIPS
    plxna4 Contained in: [BAC] DKEY-98L9 (1) (order this), DKEY-247M22 (1) (order this)
    plxna4 Encodes: [EST] eu1056 (1), eu2440 (1), fd49b01, fe15f03, wz10875 (1)
    [cDNA] MGC:194791 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004495 (1) 5712 nt
    Genomic GenBank:BX537358 (1) 230105 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DK42 (1) 1903 aa
    Sequence Information (all 29)
    ORTHOLOGY for plxna4 ( Chr: 4 )
    CITATIONS (42)