ZFIN ID: ZDB-GENE-030131-4648
Gene Name: transcobalamin II
Gene Symbol: tcn2    Nomenclature History

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Previous Names: tcn2l, si:ch211-102c2.6, wu:fd46e10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to localize to extracellular space. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in Parkinson's disease; congenital intrinsic factor deficiency; megaloblastic anemia; pernicious anemia; and transcobalamin II deficiency. Orthologous to several human genes including TCN2 (transcobalamin 2).
Genome Resources: Alliance (1),  Gene:407646 (1),  Ensembl(GRCz11):ENSDARG00000036481 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 2 publications
Directly Submitted Expression Data: 6 figures (3 images) from Thisse et al., 2004 [IMAGE:7162514]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16018 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33607 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40433 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45202 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf3057 Indel Unknown Unknown CRISPR
    zf3058 Indel Unknown Exon Loss of Exon 2 CRISPR
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tcn2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    transcobalamin II deficiency Alliance Transcobalamin II deficiency 275350
    DISEASE ASSOCIATED WITH tcn2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cobalamin transport (more)
    Cellular Component extracellular space (more)
    Molecular Function cobalamin binding (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tcn2-201 (1)    Ensembl 2001
    tcn2-202 (1)    Ensembl 772
    tcn2-203 (1)    Ensembl 540
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcn2 No data available
    MARKER RELATIONSHIPS
    tcn2 Contained in: [BAC] CH211-102C2 (1)
    tcn2 Encodes: [EST] fd46e10, IMAGE:7162514 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001123231 (1) 2001 nt
    Genomic GenBank:CU041374 (1) 141040 nt
    Select Tool
    Polypeptide UniProtKB:Q6PG35 (1) 429 aa
    Sequence Information (all 14)
    ORTHOLOGY for tcn2 ( Chr: 5 )
    CITATIONS (19)