Gene

tcn2

ID
ZDB-GENE-030131-4648
Name
transcobalamin II
Symbol
tcn2 Nomenclature History
Previous Names
  • tcn2l
  • si:ch211-102c2.6
  • wu:fd46e10 (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits cobalamin binding activity. Predicted to be involved in cobalamin transport. Predicted to localize to extracellular space. Is expressed in intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Parkinson's disease; congenital intrinsic factor deficiency; megaloblastic anemia; pernicious anemia; and transcobalamin II deficiency. Orthologous to several human genes including TCN2 (transcobalamin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcn2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
transcobalamin II deficiency Alliance Transcobalamin II deficiency 275350
Associated With tcn2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR027954 Domain of unknown function DUF4430
Family IPR002157 Cobalamin (vitamin B12)-binding protein
Domain Details Per Protein
Protein Length Cobalamin (vitamin B12)-binding protein Domain of unknown function DUF4430
UniProtKB:F2Z4S3 423
UniProtKB:Q6PG35 429
UniProtKB:F1QJR9 180
UniProtKB:F2Z4S7 245
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations