Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-4606
Gene Name: coagulation factor II (thrombin)
Gene Symbol: f2
Previous Names: prothrombin (1), wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:6903359]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  liver, whole organism, YSL
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: sa10601, sa21024
Knockdown reagents: MO1-f2 (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Dysprothrombinemia 613679
Hypoprothrombinemia 613679
Thrombophilia due to thrombin defect 188050
{Pregnancy loss, recurrent, susceptibility to, 2} 614390
{Stroke, ischemic, susceptibility to} 601367
GENE ONTOLOGY
Ontology GO Term
Biological Process blood coagulation (more)
Cellular Component extracellular region (more)
Molecular Function serine-type peptidase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000001 (1)
  • InterPro:IPR000294 (1)
  • InterPro:IPR001254 (1)
  • InterPro:IPR001314 (1)
  • InterPro:IPR003966 (1)
  • InterPro:IPR009003 (1)
  • InterPro:IPR013806 (1)
  • InterPro:IPR017857 (1)
  • InterPro:IPR018056 (1)
  • InterPro:IPR018114 (1)
  • InterPro:IPR018992 (1)
  • PROSITE:PS00011 (1)
  • PROSITE:PS00021 (1)
  • PROSITE:PS00134 (1)
  • PROSITE:PS00135 (1)
  • PROSITE:PS50070 (1)
  • PROSITE:PS50240 (1)
  • PROSITE:PS50998 (1)
  • Pfam:PF00051 (1)
  • Pfam:PF00089 (1)
  • Pfam:PF00594 (1)
  • Pfam:PF09396 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA f2-001 (1) 2424
    f2-002 (1) 1729
    ncRNA f2-003 (1) 730
    f2-004 (1) 762
    f2-005 (1) 780
    f2-006 (1) 294
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM f2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    f2 Contained in: [BAC] DKEY-23N7 (1)
    f2 Contains: [SNP] rs3728083 (1)
    f2 Encodes: [EST] fb57c10, fd42e09, fd59d01 (1), IMAGE:6903359 (1) (order this)
    [cDNA] MGC:66319 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213390 (1) 1709 bp
    Genomic GenBank:BX957256 (1) 227909 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7FAN5 (1) 635 aa
    Sequence Clusters UniGene:26855 (1)
    Sequence Information (all 20)
    OTHER f2 GENE PAGES
  • Gene:325881 (1)
  • VEGA:OTTDARG00000020221 (1)
  • Ensembl(Zv9):ENSDARG00000036041 (1)
  • MAPPING INFORMATION
    Chr: 7 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish f2 7  
    Human F2 11 (11p11)
  • OMIM:176930
  • Gene:2147
  • Mouse F2 2 ( 50.63 cM)
  • MGI:88380
  • Gene:14061
  • CITATIONS (24)