ZFIN ID: ZDB-GENE-030131-4606
Gene Name: coagulation factor II (thrombin)
Gene Symbol: f2
Previous Names: prothrombin (1), wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319
Location: Chr: 7   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:6903359]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  liver, whole organism, YSL
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-f2 (1)

Allele Type Mutagen Suppliers
sa10601 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21024 Point Mutation ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH f2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    prothrombin deficiency Dysprothrombinemia 613679
    Hypoprothrombinemia 613679
    thrombophilia Thrombophilia due to thrombin defect 188050
    cerebrovascular disease {Stroke, ischemic, susceptibility to} 601367
    {Pregnancy loss, recurrent, susceptibility to, 2} 614390
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component extracellular region (more)
    Molecular Function serine-type peptidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000001 (1)
  • InterPro:IPR000294 (1)
  • InterPro:IPR001254 (1)
  • InterPro:IPR001314 (1)
  • InterPro:IPR003966 (1)
  • InterPro:IPR009003 (1)
  • InterPro:IPR012224 (1)
  • InterPro:IPR013806 (1)
  • InterPro:IPR017857 (1)
  • InterPro:IPR018056 (1)
  • InterPro:IPR018114 (1)
  • InterPro:IPR018992 (1)
  • PROSITE:PS00011 (1)
  • PROSITE:PS00021 (1)
  • PROSITE:PS00134 (1)
  • PROSITE:PS00135 (1)
  • PROSITE:PS50070 (1)
  • PROSITE:PS50240 (1)
  • PROSITE:PS50998 (1)
  • Pfam:PF00051 (1)
  • Pfam:PF00089 (1)
  • Pfam:PF00594 (1)
  • Pfam:PF09396 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA f2-001 (1) 2424
    f2-002 (1) 1729
    ncRNA f2-003 (1) 730
    f2-004 (1) 762
    f2-005 (1) 780
    f2-006 (1) 294
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM f2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    f2 Contained in: [BAC] DKEY-23N7 (1) (order this)
    f2 Contains: [SNP] rs3728083 (1)
    f2 Encodes: [EST] fb57c10, fd42e09, fd59d01 (1), IMAGE:6903359 (1) (order this)
    [cDNA] MGC:66319 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213390 (1) 1709 bp
    Genomic GenBank:BX957256 (1) 227909 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7FAN5 (1) 635 aa
    Sequence Clusters UniGene:26855 (1)
    Sequence Information (all 20)
    OTHER f2 GENE PAGES
  • Gene:325881 (1)
  • VEGA:OTTDARG00000020221 (1)
  • Ensembl(Zv9):ENSDARG00000036041 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish f2 7  
    Human F2 11 (11p11)
  • OMIM:176930
  • Gene:2147
  • Mouse F2 2 ( 50.63 cM)
  • MGI:88380
  • Gene:14061
  • Orthology Details
    CITATIONS (25)