ZFIN ID: ZDB-GENE-030131-4606
Gene Name: coagulation factor II (thrombin)
Gene Symbol: f2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: prothrombin (1), wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Involved in blood coagulation. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including appendicitis; artery disease (multiple); autoimmune hypersensitivity disease (multiple); inherited blood coagulation disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).
Genome Resources: Alliance (1),  Gene:325881 (1),  Ensembl(GRCz11):ENSDARG00000036041 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 6 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:6903359]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10601 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21024 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-f2 N/A 3
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH f2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cerebral infarction Alliance {Stroke, ischemic, susceptibility to} 601367
    prothrombin deficiency Alliance Dysprothrombinemia 613679
    Hypoprothrombinemia 613679
    prothrombin thrombophilia Alliance Thrombophilia due to thrombin defect 188050
    thrombophilia due to thrombin defect Alliance Thrombophilia due to thrombin defect 188050
    {Pregnancy loss, recurrent, susceptibility to, 2} 614390
    DISEASE ASSOCIATED WITH f2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component extracellular region (more)
    Molecular Function serine-type peptidase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA f2-201 (1)    Ensembl 2424
    f2-202 (1)    Ensembl 1729
    f2-204 (1)    Ensembl 762
    ncRNA f2-003 (1)    Ensembl 1323
    f2-006 (1)    Ensembl 294
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM f2 No data available
    MARKER RELATIONSHIPS
    f2 Contained in: [BAC] DKEY-23N7 (1) (order this)
    f2 Contains: [SNP] rs3728083 (1)
    f2 Encodes: [EST] fb57c10, fd42e09, fd59d01 (1), IMAGE:6903359 (1)
    [cDNA] MGC:66319 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213390 (1) 1709 nt
    Genomic GenBank:BX957256 (1) 227909 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7FAN5 (1) 635 aa
    Sequence Information (all 21)
    ORTHOLOGY for f2 ( Chr: 7 )
    CITATIONS (36)