ZFIN ID: ZDB-GENE-030131-4606
Gene Name: coagulation factor II (thrombin)
Gene Symbol: f2
Previous Names: prothrombin (1), wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:6903359]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  liver, whole organism, YSL
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10601 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21024 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-f2 (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH f2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cerebrovascular disease {Stroke, ischemic, susceptibility to} 601367
    prothrombin deficiency Dysprothrombinemia 613679
    Hypoprothrombinemia 613679
    thrombophilia Thrombophilia due to thrombin defect 188050
    {Pregnancy loss, recurrent, susceptibility to, 2} 614390
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component extracellular region (more)
    Molecular Function serine-type peptidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000001 (1)
  • InterPro:IPR000294 (1)
  • InterPro:IPR001254 (1)
  • InterPro:IPR001314 (1)
  • InterPro:IPR003966 (1)
  • InterPro:IPR009003 (1)
  • InterPro:IPR012224 (1)
  • InterPro:IPR013806 (1)
  • InterPro:IPR017857 (1)
  • InterPro:IPR018056 (1)
  • InterPro:IPR018114 (1)
  • InterPro:IPR018992 (1)
  • InterPro:IPR033116 (1)
  • PROSITE:PS00011 (1)
  • PROSITE:PS00021 (1)
  • PROSITE:PS00134 (1)
  • PROSITE:PS00135 (1)
  • PROSITE:PS50070 (1)
  • PROSITE:PS50240 (1)
  • PROSITE:PS50998 (1)
  • Pfam:PF00051 (1)
  • Pfam:PF00089 (1)
  • Pfam:PF00594 (1)
  • Pfam:PF09396 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA f2-001 (1) 2424
    f2-002 (1) 1729
    ncRNA f2-003 (1) 1323
    mRNA f2-004 (1) 762
    ncRNA f2-006 (1) 294
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM f2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    f2Contained in: [BAC] DKEY-23N7 (1) (order this)
    f2Contains: [SNP] rs3728083 (1)
    f2Encodes: [EST] fb57c10, fd42e09, fd59d01 (1), IMAGE:6903359 (1) (order this)
    [cDNA] MGC:66319 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213390 (1) 1709bp
    Genomic GenBank:BX957256 (1) 227909bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7FAN5 (1) 635aa
    Sequence Clusters UniGene:26855 (1)
    Sequence Information (all 21)
    OTHER f2 GENE PAGES
  • Gene:325881 (1)
  • VEGA:OTTDARG00000020221 (1)
  • Ensembl(GRCz10):ENSDARG00000036041 (1)
  • ORTHOLOGY for f2 (Chr: 7)
    Species Symbol Chromosome Accession # Evidence
    Human F2 11
  • Gene:2147
  • OMIM:176930
  • HGNC:3535
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse F2 2
  • MGI:88380
  • Gene:14061
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (25)