ZFIN ID: ZDB-GENE-030131-4606
Gene Name: coagulation factor II (thrombin)
Gene Symbol: f2
Sequence Ontology ID : SO:0000704

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Previous Names: prothrombin (1), wu:fb57c10, wu:fd42e09, wu:fd59d01, zgc:66319

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(Including Attributions)
Location: Chr: 7 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [IMAGE:6903359]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
  liver, whole organism, YSL
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10601 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21024 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-f2 (1)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH f2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cerebrovascular disease {Stroke, ischemic, susceptibility to} 601367
    prothrombin deficiency Dysprothrombinemia 613679
    Hypoprothrombinemia 613679
    thrombophilia Thrombophilia due to thrombin defect 188050
    {Pregnancy loss, recurrent, susceptibility to, 2} 614390
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Cellular Component extracellular region (more)
    Molecular Function serine-type peptidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000001
  • InterPro:IPR000294
  • InterPro:IPR001254
  • InterPro:IPR001314
  • InterPro:IPR003966
  • InterPro:IPR009003
  • InterPro:IPR012224 (1)
  • InterPro:IPR013806
  • InterPro:IPR017857
  • InterPro:IPR018056
  • InterPro:IPR018114
  • InterPro:IPR018992
  • InterPro:IPR033116
  • PROSITE:PS00011
  • PROSITE:PS00021
  • PROSITE:PS00134
  • PROSITE:PS00135
  • PROSITE:PS50070
  • PROSITE:PS50240
  • PROSITE:PS50998
  • Pfam:PF00051
  • Pfam:PF00089
  • Pfam:PF00594
  • Pfam:PF09396
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA f2-001 (1) 2424
    f2-002 (1) 1729
    ncRNA f2-003 (1) 1323
    mRNA f2-004 (1) 762
    ncRNA f2-006 (1) 294
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM f2 No data available
    MARKER RELATIONSHIPS
    f2Contained in: [BAC] DKEY-23N7 (1) (order this)
    f2Contains: [SNP] rs3728083 (1)
    f2Encodes: [EST] fb57c10, fd42e09, fd59d01 (1), IMAGE:6903359 (1) (order this)
    [cDNA] MGC:66319 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213390 (1) 1709bp
    Genomic GenBank:BX957256 (1) 227909bp Blast at MegaBLAST
    Polypeptide UniProtKB:E7FAN5 635aa
    Sequence Clusters UniGene:26855 (1)
    Sequence Information (all 23)
    OTHER f2 GENE PAGES
  • Alliance (1)
  • Gene:325881 (1)
  • VEGA:OTTDARG00000020221 (1)
  • Ensembl(GRCz10):ENSDARG00000036041 (1)
  • ORTHOLOGY for f2 (Chr: 7)
    CITATIONS (28)