Gene
pcm1
- ID
- ZDB-GENE-030131-428
- Name
- pericentriolar material 1
- Symbol
- pcm1 Nomenclature History
- Previous Names
-
- wu:fb30g01
- wu:fb94e03
- wu:fe14f07
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be involved in microtubule anchoring at centrosome; non-motile cilium assembly; and protein localization to centrosome. Predicted to act upstream of or within cilium assembly. Located in centrosome. Is expressed in head and post-vent region. Orthologous to human PCM1 (pericentriolar material 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148350 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021003Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1869 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa6578 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19460 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39576 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39577 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pcm1 | Monroe et al., 2020 | |
| CRISPR2-pcm1 | Monroe et al., 2020 | |
| CRISPR3-pcm1 | Monroe et al., 2020 | |
| MO1-pcm1 | N/A | Stowe et al., 2012 |
| MO2-pcm1 | N/A | Monroe et al., 2020 |
| MO3-pcm1 | N/A | Monroe et al., 2020 |
1 - 6 of 6
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Pericentriolar material 1 protein | Pericentriolar material 1 protein, C-terminal |
|---|---|---|---|---|
| UniProtKB:A0A8M3B520 | InterPro | 2053 | ||
| UniProtKB:A0A8M9PSA8 | InterPro | 2076 | ||
| UniProtKB:A0A8M3AYV7 | InterPro | 2042 | ||
| UniProtKB:A0A8M9QAU8 | InterPro | 2079 | ||
| UniProtKB:A0A8M1NI52 | InterPro | 2018 | ||
| UniProtKB:A0A8M9QB62 | InterPro | 2037 | ||
| UniProtKB:A0A8M9PSD5 | InterPro | 2064 | ||
| UniProtKB:A0A8M9QFL3 | InterPro | 2068 | ||
| UniProtKB:A0A8M9QJV5 | InterPro | 2060 | ||
| UniProtKB:A0A8M9QFV9 | InterPro | 2030 | ||
| UniProtKB:A0AB32TTX6 | InterPro | 2050 | ||
| UniProtKB:A0AB32TWP6 | InterPro | 2004 | ||
| UniProtKB:A0AB32TZ17 | InterPro | 2011 | ||
| UniProtKB:A0AB32U1V3 | InterPro | 2034 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-1B13 | ||
| Contained in | BAC | CH211-226M23 | ZFIN Curated Data | |
| Contains | SNP | rs3727497 | ZFIN Curated Data | |
| Contains | SNP | rs3727502 | ZFIN Curated Data | |
| Contains | SNP | rs3727503 | ZFIN Curated Data | |
| Contains | SNP | rs3727504 | ZFIN Curated Data | |
| Contains | SNP | rs3727505 | ZFIN Curated Data | |
| Contains | SNP | rs3727506 | ZFIN Curated Data | |
| Contains | SNP | rs3727507 | ZFIN Curated Data | |
| Contains | SNP | rs3727508 | ZFIN Curated Data |
1 - 10 of 20
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115123 (1) | 6890 nt | ||
| Genomic | GenBank:BX927415 (1) | 202881 nt | ||
| Polypeptide | UniProtKB:A0A8M9QAU8 (1) | 2079 aa |
- Li, J., Liu, F., Lv, Y., Sun, K., Zhao, Y., Reilly, J., Zhang, Y., Tu, J., Yu, S., Liu, X., Qin, Y., Huang, Y., Gao, P., Jia, D., Chen, X., Han, Y., Shu, X., Luo, D., Tang, Z., Liu, M. (2021) Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing. Nucleic acids research. 49(4):2027-2043
- Monroe, T.O., Garrett, M.E., Kousi, M., Rodriguiz, R.M., Moon, S., Bai, Y., Brodar, S.C., Soldano, K.L., Savage, J., Hansen, T.F., Muzny, D.M., Gibbs, R.A., Barak, L., Sullivan, P.F., Ashley-Koch, A.E., Sawa, A., Wetsel, W.C., Werge, T., Katsanis, N. (2020) PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. Nature communications. 11:5903
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Stowe, T.R., Wilkinson, C.J., Iqbal, A., and Stearns, T. (2012) The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Molecular biology of the cell. 23(17):3322-3335
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Kelly, P.D., Chu, F., Ngo-Hazelett, P., Yan, Y.-L., Huang, H., Postlethwait, J.H., and Talbot, W.S. (2000) A comparative map of the zebrafish genome. Genome research. 10(12):1903-1914
1 - 8 of 8
Show