ZFIN ID: ZDB-GENE-030131-4265
Gene Name: signal peptide peptidase-like 2
Gene Symbol: sppl2
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fc16e01, wu:fc85d12, zgc:136525

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 2 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have aspartic endopeptidase activity, intramembrane cleaving; involved in negative regulation of coagulation; predicted to localize to the cytoplasmic part and intracellular organelle;  ...
GENE EXPRESSION
All Expression Data: Fig. 4 from Krawitz et al., 2005
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Segmentation:20-25 somites (19.0h-22.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023657Tg Transgenic Insertion Unknown Unknown DNA
sa16700 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: Fig. 3 from Pickart et al., 2006
    Observed in:
    DISEASE ASSOCIATED WITH sppl2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sppl2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of coagulation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function aspartic endopeptidase activity, intramembrane cleaving (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003137 (1)
  • InterPro:IPR006639 (1)
  • InterPro:IPR007369 (1)
  • InterPro:IPR033149 (1)
  • Pfam:PF02225 (1)
  • Pfam:PF04258 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA sppl2-201 (1) 2851
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM sppl2 No data available
    MARKER RELATIONSHIPS
    sppl2Contained in: [BAC] DKEY-57K2 (1) (order this)
    sppl2Encodes: [EST] fc16e01, fc85d12
    [cDNA] MGC:55854 (1) (order this), MGC:136525 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045244 (1) 2076bp
    Genomic GenBank:BX539340 (1) 234470bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5BP99 (1) 564aa
    Sequence Clusters UniGene:78453 (1)
    Sequence Information (all 28)
    OTHER sppl2 GENE PAGES
  • Alliance (1)
  • Gene:325540 (1)
  • VEGA:OTTDARG00000019937 (1)
  • Ensembl(GRCz11):ENSDARG00000030448 (2)
  • ORTHOLOGY for sppl2 (Chr: 2)
    CITATIONS (22)