Gene

hmg20b

ID

ZDB-GENE-030131-4258

Name

high mobility group 20B

Symbol

hmg20b Nomenclature History

Previous Names

fc85b02
si:dkey-110c1.6 (1)
wu:fc85b02 (1)
zgc:110001

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Orthologous to human HMG20B (high mobility group 20B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110001 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa17207	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa24153	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa29763	Allele with one point mutation	Unknown	Premature Stop	ENU
sa37496	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With hmg20b Human Ortholog

No data available

Associated With hmg20b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Family	IPR051965	Chromatin Regulation and Neuronal Gene Expression
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Chromatin Regulation and Neuronal Gene Expression	High mobility group box domain	High mobility group box domain superfamily
UniProtKB:Q503Z1	InterPro	301
UniProtKB:A0A0R4IWQ8	InterPro	298

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 22

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hmg20b-201 (1) Ensembl	Ensembl	1,555 nt	Select Tool ZFIN BLAST
mRNA	hmg20b-202 (1) Ensembl	Ensembl	1,075 nt	Select Tool ZFIN BLAST
mRNA	hmg20b-203 (1) Ensembl	Ensembl	4,652 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-110C1	BX005203	ZFIN Curated Data
Contained in	BAC	DKEY-268M13	BX293565	ZFIN Curated Data
Encodes	EST	fc85b02	AI943143 AI964977
Encodes	cDNA	MGC:110001	BC095120	ZFIN Curated Data
Encodes	cDNA	MGC:162377	BC134979	ZFIN Curated Data
Encodes	cDNA	MGC:191243	BC164068	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001020551 (1)	1558 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005203 (1)	214813 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:Q503Z1 (1)	301 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	HMG20B	19	Ensembl:ENSG00000064961 Gene:10362 HGNC:5002 OMIM:605535	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Hmg20b	10	Ensembl:ENSMUSG00000020232 Gene:15353 MGI:1341190	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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