ZFIN ID: ZDB-GENE-030131-417
Gene Name: plakophilin 1b
Gene Symbol: pkp1b    Nomenclature History

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Previous Names: pkp1, fb30d08, wu:fb30d08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have cadherin binding activity. Predicted to be involved in cell-cell adhesion; cell-cell junction assembly; and intermediate filament bundle assembly. Predicted to localize to several cellular components, including adherens junction; nucleus; and plasma membrane. Is expressed in EVL; otic vesicle; peripheral olfactory organ; and pharyngeal arch. Human ortholog(s) of this gene implicated in ectodermal dysplasia. Orthologous to human PKP1 (plakophilin 1).
Genome Resources: Alliance (1),  Gene:797838 (1),  Ensembl(GRCz11):ENSDARG00000052705 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2004 [IMAGE:7152279]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025681Tg Transgenic Insertion Unknown Unknown DNA
la025682Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40802 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pkp1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Ectodermal dysplasia/skin fragility syndrome 604536
    DISEASE ASSOCIATED WITH pkp1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component desmosome (more)
    Molecular Function cadherin binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pkp1b-201 (1)    Ensembl 2833
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pkp1b No data available
    MARKER RELATIONSHIPS
    pkp1b Contained in: [BAC] DKEY-70O1 (1) (order this)
    pkp1b Encodes: [EST] fb30d08, IMAGE:7152279 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001338263 (1)
    Genomic GenBank:CR847929 (1) 198536 nt
    Select Tool
    Polypeptide UniProtKB:E7FBR0 (1) 736 aa
    Sequence Information (all 9)
    ORTHOLOGY for pkp1b ( Chr: 6 )
    CITATIONS (22)