ZFIN ID: ZDB-GENE-030131-4042
Gene Name: calreticulin
Gene Symbol: calr    Nomenclature History

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Previous Names: calrl2, fc66d10, wu:fc66d10, wu:fj50c03, zgc:66153

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein folding. Predicted to localize to endoplasmic reticulum membrane. Is expressed in several structures, including hatching gland; nervous system; notochord; polster; and trigeminal placode. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin).
Genome Resources: Alliance (1),  Gene:325317 (1),  Ensembl(GRCz11):ENSDARG00000076290 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029433Tg Transgenic Insertion Unknown Unknown DNA
sa17516 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH calr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    essential thrombocythemia Alliance Thrombocythemia, somatic 187950
    myelofibrosis Alliance Myelofibrosis, somatic 254450
    DISEASE ASSOCIATED WITH calr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein folding (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA calr-201 (1)    Ensembl 2513
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM calr
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(gnat2:calr-GFP) gnat2 calrGFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    calr Contained in: [BAC] CH73-22B20 (1)
    calr Encodes: [EST] fc66d10, fj50c03 (1)
    [cDNA] MGC:66153 (1), MGC:191899 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199713 (1) 2532 nt
    Genomic GenBank:CU467861 (1) 156586 nt
    Select Tool
    Polypeptide UniProtKB:Q6PFP8 (1) 419 aa
    Sequence Information (all 19)
    ORTHOLOGY for calr ( Chr: 8 )
    CITATIONS (35)