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ZIRC
ZFIN ID: ZDB-GENE-030131-4022
Gene Name: GREB1 like retinoic acid receptor coactivator
Gene Symbol: greb1l    Nomenclature History

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Previous Names: fc65f09, si:dkey-203o21.1, si:dkey-264l15.1, wu:fc55e03, wu:fc65f09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Involved in pronephros development. Predicted to localize to the integral component of membrane. Used to study renal agenesis. Human ortholog(s) of this gene implicated in renal agenesis. Is expressed in central nervous system and mesoderm. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).
Genome Resources: Alliance (1),  Gene:100005373 (1),  Ensembl(GRCz11):ENSDARG00000039196 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rdu1000 Small Deletion Exon 8 Unknown CRISPR
sa1260 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1657 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa5124 Point Mutation Unknown Premature Stop ENU
    sa14368 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16374 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16854 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17608 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19691 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25771 Point Mutation Unknown Premature Stop ENU
    sa32856 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-greb1l
    1
    CRISPR2-greb1l 1
    CRISPR3-greb1l
    1
    MO1-greb1l N/A 1
    MO2-greb1l N/A 1
    DISEASE ASSOCIATED WITH greb1l HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Renal hypodysplasia/aplasia 3 617805
    DISEASE ASSOCIATED WITH greb1l VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    renal agenesis greb1lrdu1000/rdu1000 standard conditions Sanna-Cherchi et al., 2017
    EKW + MO2-greb1l standard conditions Sanna-Cherchi et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process kidney development (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR024840 (1)
  • InterPro:IPR028422 (1)
  • Pfam:PF15782 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA greb1l-203 (1)    Ensembl 9009
    ncRNA greb1l-002 (1) 851
    Browsers: UCSCEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM greb1l No data available
    MARKER RELATIONSHIPS
    greb1l Contained in: [BAC] CH73-337F15 (1) (order this), DKEY-203O21 (1) (order this), DKEY-264L15 (1) (order this)
    greb1l Encodes: [EST] fc55e03, fc65f09, wz13009
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001362307 (1)
    Genomic GenBank:CT573467 (1) 102014 bp
    Select Tool
    Polypeptide UniProtKB:B8JKP6 (1) 1942 aa
    Sequence Clusters UniGene:79031 (1)
    Sequence Information (all 33)
    ORTHOLOGY for greb1l ( Chr: 2 )
    CITATIONS (26)