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ZIRC
ZFIN ID: ZDB-GENE-030131-4017
Gene Name: NOP2/Sun RNA methyltransferase 2
Gene Symbol: nsun2    Nomenclature History

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Previous Names: wu:fc65a08, zgc:55517

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA methylation. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2).
Genome Resources: Alliance (1),  Gene:325292 (1),  Ensembl(GRCz11):ENSDARG00000056665 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55517]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb340 Indel Exon 3 Unknown CRISPR
ihb341 Indel Exon 3 Unknown CRISPR
sa3016 Point Mutation Unknown Premature Stop ENU
sa14653 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15958 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36858 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43300 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nsun2 1
    CRISPR2-nsun2 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nsun2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 5 611091
    DISEASE ASSOCIATED WITH nsun2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process methylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function methyltransferase activity (more)
    GO Terms (all 9)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nsun2-202 (1)    Ensembl 2893
    ncRNA nsun2-002 (1)    Ensembl 563
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nsun2 No data available
    MARKER RELATIONSHIPS
    nsun2 Contained in: [BAC] DKEY-56D18 (1) (order this)
    nsun2 Encodes: [EST] fc65a08
    [cDNA] MGC:55517 (1) (order this), MGC:191743 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199711 (1) 2905 bp
    Genomic GenBank:BX511155 (1) 205235 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A5PMI3 (1) 766 aa
    Sequence Clusters UniGene:119317 (1)
    Sequence Information (all 18)
    ORTHOLOGY for nsun2 ( Chr: 19 )
    CITATIONS (21)