Gene

nsun2

ID
ZDB-GENE-030131-4017
Name
NOP2/Sun RNA methyltransferase 2
Symbol
nsun2 Nomenclature History
Previous Names
  • wu:fc65a08
  • zgc:55517
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable tRNA (cytosine-5-)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nsun2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 5 Alliance Intellectual developmental disorder, autosomal recessive 5 611091
Associated With nsun2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type
Family IPR023267 RNA (C5-cytosine) methyltransferase
Family IPR023270 tRNA (C5-cytosine) methyltransferase, NCL1
Domain Details Per Protein
Protein Length RNA (C5-cytosine) methyltransferase SAM-dependent methyltransferase RsmB/NOP2-type tRNA (C5-cytosine) methyltransferase, NCL1
UniProtKB:Q7ZTI1 706
UniProtKB:A5PMI3 766
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations