ZFIN ID: ZDB-GENE-030131-3813
Gene Name: MKS transition zone complex subunit 1
Gene Symbol: mks1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fc54h05, si:dkey-189h5.2, wu:fc54h05, zgc:153149

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in dorsal convergence. Predicted to localize to MKS complex. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 13; Joubert syndrome 28; and Meckel syndrome 1. Orthologous to human MKS1 (MKS transition zone complex subunit 1).
Genome Resources: Alliance (1),  Gene:556706 (1),  Ensembl(GRCz11):ENSDARG00000059657 (1)
GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7574 Point Mutation Unknown Missense ENU
sa20540 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40567 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • w152 Insertion Unknown Frameshift CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mks1 1
    CRISPR2-mks1
    1
    MO1-mks1 N/A 2
    MO2-mks1 N/A 4
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH mks1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bardet-Biedl syndrome 13 Alliance Bardet-Biedl syndrome 13 615990
    Joubert syndrome 28 Alliance Joubert syndrome 28 617121
    Meckel syndrome 1 Alliance Meckel syndrome 1 249000
    DISEASE ASSOCIATED WITH mks1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    ciliopathy WT + MO2-mks1 control Tobin et al., 2008
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal convergence (more)
    Cellular Component MKS complex (more)
    Molecular Function molecular_function (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mks1-201 (1)    Ensembl 2066
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mks1 No data available
    MARKER RELATIONSHIPS
    mks1 Contained in: [BAC] DKEY-189H5 (1) (order this)
    mks1 Encodes: [EST] fc54h05
    [cDNA] MGC:153149 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077373 (1)
    Genomic GenBank:CR753838 (1) 188660 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RPF9 (1) 559 aa
    Sequence Information (all 13)
    ORTHOLOGY for mks1 ( Chr: 5 )
    CITATIONS (24)