ZFIN ID: ZDB-GENE-030131-3671
Gene Name: adhesion G protein-coupled receptor G1
Gene Symbol: adgrg1    Nomenclature History

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Previous Names: fc49b10, gpr56, wu:fc49b10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor activity. Involved in glial cell development and regulation of oligodendrocyte progenitor proliferation. Predicted to localize to the integral component of plasma membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and trigeminal placode. Orthologous to several human genes including ADGRG1 (adhesion G protein-coupled receptor G1).
Genome Resources: Alliance (1),  Gene:324948 (1), 
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [IMAGE:7159602]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8480 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8769 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11235 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20955 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20956 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34083 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • stl13 Small Deletion Unknown Unknown TALEN
    stl14 Small Deletion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-adgrg1 1
    DISEASE ASSOCIATED WITH adgrg1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Polymicrogyria, bilateral frontoparietal 606854
    Polymicrogyria, bilateral perisylvian 615752
    DISEASE ASSOCIATED WITH adgrg1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination of posterior lateral line nerve axons (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000203 GPS motif
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR001315 CARD domain
    Domain IPR017981 GPCR, family 2-like
    Family IPR000832 GPCR, family 2, secretin-like
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR011029 Death-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adgrg1-201 (1)    Ensembl 2823
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adgrg1 No data available
    MARKER RELATIONSHIPS
    adgrg1 Contained in: [BAC] DKEY-181F22 (1) (order this)
    adgrg1 Encodes: [EST] fc49b10, IMAGE:7159602 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020481 (1) 1947 nt
    Genomic GenBank:CU464087 (1) 155817 nt
    Select Tool
    Polypeptide UniProtKB:F1QZM9 (1) 648 aa
    Sequence Information (all 13)
    ORTHOLOGY for adgrg1 ( Chr: 7 )
    CITATIONS (19)