ZFIN ID: ZDB-GENE-030131-3663
Gene Name: alanyl-tRNA synthetase 1
Gene Symbol: aars1    Nomenclature History

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Previous Names: aars, im:7146712, si:ch211-223o1.6, wu:fc48h07, zgc:113920 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have anion binding activity; catalytic activity, acting on a tRNA; and tRNA binding activity. Predicted to be involved in mitochondrial alanyl-tRNA aminoacylation and tRNA modification. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N and early infantile epileptic encephalopathy 29. Orthologous to human AARS1 (alanyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:324940 (1),  Ensembl(GRCz11):ENSDARG00000069142 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:113920]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7151191]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7146712]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9719 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36623 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-aars1
    1
    MO1-aars1 N/A 1
    MO2-aars1 N/A 1
    MO3-aars1 N/A 1
    DISEASE ASSOCIATED WITH aars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease axonal type 2N Alliance Charcot-Marie-Tooth disease, axonal, type 2N 613287
    early infantile epileptic encephalopathy 29 Alliance Epileptic encephalopathy, early infantile, 29 616339
    DISEASE ASSOCIATED WITH aars1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process alanyl-tRNA aminoacylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function alanine-tRNA ligase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aars-202 (1)    Ensembl 3617
    aars-203 (1)    Ensembl 3688
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aars1 No data available
    MARKER RELATIONSHIPS
    aars1 Contained in: [BAC] CH211-223O1 (1)
    aars1 Encodes: [EST] fc48h07, IMAGE:7146712 (1), IMAGE:7151191 (1)
    [cDNA] MGC:113920 (1), MGC:158129 (1), MGC:198394 (1), MGC:198396 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044310 (1) 3688 nt
    Genomic GenBank:BX649641 (1) 141018 nt
    Select Tool
    Polypeptide UniProtKB:Q1LVL3 (1) 991 aa
    Sequence Information (all 37)
    ORTHOLOGY for aars1 ( Chr: 18 )
    CITATIONS (30)