ZFIN ID: ZDB-GENE-030131-3606
Gene Name: microtubule actin crosslinking factor 1a
Gene Symbol: macf1a    Nomenclature History

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Previous Names: acf7a (1), macf1, fc46g01, magellan (1), mgn (1), si:rp71-45k5.7, wu:fc46g01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Involved in oocyte animal/vegetal axis specification and organelle disassembly. Localizes to cell cortex and mitochondrial cloud. Predicted to colocalize with intermediate filament. Is expressed in hair cell anterior macula; inner ear; macula; oocyte stage I; and posterior crista. Human ortholog(s) of this gene implicated in lissencephaly. Orthologous to human MACF1 (microtubule actin crosslinking factor 1).
Genome Resources: Alliance (1),  Gene:562190 (1),  Ensembl(GRCz11):ENSDARG00000028533 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct68aGt Transgenic Insertion Unknown Unknown DNA
la011208Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020792Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p1CH1 Small Deletion Unknown Exon Loss of Exon 5 CRISPR
    p2CH1CH2 Small Deletion Unknown Exon Loss of Exon 4 CRISPR
    p3PRD Small Deletion Unknown Exon Loss of Exon 36 CRISPR
    p6cv Small Deletion Unknown Frameshift, Premature Stop
    p11cv Small Deletion Unknown Frameshift, Premature Stop ENU
    p57bjta Unknown Unknown Unknown
    sa11432 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12481 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12708 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13865 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15741 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17558 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23565 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23566 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25094 Point Mutation Unknown Premature Stop ENU
    sa32250 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36877 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36878 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36879 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36880 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36881 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39255 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43317 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43318 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45679 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-macf1a 1
    CRISPR2-macf1a 1
    CRISPR3-macf1a 1
    CRISPR4-macf1a 1
    CRISPR5-macf1a 1
    DISEASE ASSOCIATED WITH macf1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Lissencephaly 9 with complex brainstem malformation 618325
    DISEASE ASSOCIATED WITH macf1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axis specification (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA macf1a-202 (1)    Ensembl 18608
    macf1a-203 (1)    Ensembl 684
    macf1a-204 (1)    Ensembl 898
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM macf1a No data available
    MARKER RELATIONSHIPS
    macf1a Contained in: [BAC] CH211-171A11 (1), DKEY-173J22 (1) (order this), DKEYP-116A7 (1), RP71-45K5 (1)
    macf1a Encodes: [EST] fc46g01, fa91g08
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005159665 (1)
    Genomic GenBank:BX511004 (1) 168626 nt
    Select Tool
    Polypeptide UniProtKB:F1RA35 (1) 5754 aa
    Sequence Information (all 94)
    ORTHOLOGY for macf1a ( Chr: 19 )
    CITATIONS (36)