ZFIN ID: ZDB-GENE-030131-3568
Gene Name: Kruppel-like factor 11a
Gene Symbol: klf11a    Nomenclature History

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Previous Names: klf11, si:dkey-81b15.5, TIEG2 (1), tieg3 (1), wu:fc45c07, wu:fj44b12, zgc:153255

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (Kruppel like factor 11).
Genome Resources: Alliance (1),  Gene:560787 (1),  Ensembl(GRCz11):ENSDARG00000030844 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6901241]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa988 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH klf11a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young type 7 Alliance Maturity-onset diabetes of the young, type VII 610508
    DISEASE ASSOCIATED WITH klf11a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription by RNA polymerase II (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR013087 Zinc finger C2H2-type
    Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA klf11a-201 (1)    Ensembl 2061
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM klf11a No data available
    MARKER RELATIONSHIPS
    klf11a Contained in: [BAC] DKEY-81B15 (1) (order this)
    klf11a Encodes: [EST] fc45c07, fj44b12 (1), IMAGE:6901241 (1)
    [cDNA] MGC:153255 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044941 (1) 2004 bp
    Genomic GenBank:BX248136 (1) 222316 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5RIQ4 (1) 479 aa
    Sequence Information (all 17)
    ORTHOLOGY for klf11a ( Chr: 20 )
    CITATIONS (31)