ZFIN ID: ZDB-GENE-030131-3497
Gene Name: myosin light chain kinase 3
Gene Symbol: mylk3    Nomenclature History

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Previous Names: mlck (1), cardiac-MLCK (1), fc41h03, si:rp71-34g2.1, wu:fc41h03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have myosin light chain kinase activity. Involved in heart morphogenesis; sarcomerogenesis; and ventricular cardiac myofibril assembly. Predicted to localize to cytoplasm. Is expressed in lens; notochord; pericardial region; and somite. Orthologous to human MYLK3 (myosin light chain kinase 3).
Genome Resources: Alliance (1),  Gene:561635 (1),  Ensembl(GRCz11):ENSDARG00000076348 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18088 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27022 Point Mutation Unknown Premature Stop ENU
    sa45291 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mylk3 N/A 1
    MO2-mylk3 N/A 1
    MO3-mylk3 N/A 1
    DISEASE ASSOCIATED WITH mylk3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mylk3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart morphogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mylk3-201 (1)    Ensembl 3212
    mylk3-202 (1)    Ensembl 3708
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mylk3 No data available
    MARKER RELATIONSHIPS
    mylk3 Contained in: [BAC] RP71-34G2
    mylk3 Encodes: [EST] fc41h03
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001105587 (1) 3236 nt
    Genomic GenBank:AL928906 (1) 161527 nt
    Select Tool
    Polypeptide UniProtKB:T1ECV2 (1) 874 aa
    Sequence Information (all 13)
    ORTHOLOGY for mylk3 ( Chr: 7 )
    CITATIONS (25)