Gene

dicer1

ID
ZDB-GENE-030131-3445
Name
dicer 1, ribonuclease type III
Symbol
dicer1 Nomenclature History
Previous Names
  • fc39d11
  • fc74b05
  • wu:fc39d11
  • wu:fc74b05
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits pre-miRNA binding activity. Involved in gene silencing by miRNA and nervous system development. Predicted to localize to several cellular components, including RISC complex; RISC-loading complex; and nucleus. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in multinodular goiter and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dicer1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multinodular goiter Alliance Goiter, multinodular 1, with or without Sertoli-Leydig cell tumors 138800
pleuropulmonary blastoma Alliance Pleuropulmonary blastoma 601200
GLOW syndrome, somatic mosaic 618272
Rhabdomyosarcoma, embryonal, 2 180295
Associated With dicer1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000999 Ribonuclease III domain
Domain IPR001650 Helicase, C-terminal
Domain IPR003100 PAZ domain
Domain IPR005034 Dicer dimerisation domain
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014720 Double-stranded RNA-binding domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036085 PAZ domain superfamily
Homologous_superfamily IPR036389 Ribonuclease III, endonuclease domain superfamily
Homologous_superfamily IPR038248 Dicer dimerisation domain superfamily
Domain Details Per Protein
Protein Length DEAD/DEAH box helicase domain Dicer dimerisation domain Dicer dimerisation domain superfamily Double-stranded RNA-binding domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain PAZ domain PAZ domain superfamily P-loop containing nucleoside triphosphate hydrolase Ribonuclease III domain Ribonuclease III, endonuclease domain superfamily
UniProtKB:Q6TLW3 53
UniProtKB:A0A0R4IDJ0 1905
UniProtKB:Q6TV19 1865
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations