ZFIN is now using GRCz12tu for Genomic Data
Gene
cyb5r3
- ID
- ZDB-GENE-030131-3281
- Name
- cytochrome b5 reductase 3
- Symbol
- cyb5r3 Nomenclature History
- Previous Names
-
- fc32h03
- wu:fc32h03
- zgc:77071 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables NADH dehydrogenase activity. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1002 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001433 | Oxidoreductase FAD/NAD(P)-binding |
| Domain | IPR001709 | Flavoprotein pyridine nucleotide cytochrome reductase |
| Domain | IPR008333 | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain |
| Domain | IPR017927 | FAD-binding domain, ferredoxin reductase-type |
| Family | IPR001834 | NADH:cytochrome b5 reductase-like |
| Homologous_superfamily | IPR017938 | Riboflavin synthase-like beta-barrel |
| Homologous_superfamily | IPR039261 | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-binding domain, ferredoxin reductase-type | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Flavoprotein pyridine nucleotide cytochrome reductase | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | NADH:cytochrome b5 reductase-like | Oxidoreductase FAD/NAD(P)-binding | Riboflavin synthase-like beta-barrel |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYE6 | InterPro | 298 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyb5r3-201
(1)
|
Ensembl | 1,890 nt | ||
| mRNA |
cyb5r3-202
(1)
|
Ensembl | 537 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers