ZFIN ID: ZDB-GENE-030131-3281
Gene Name: cytochrome b5 reductase 3
Gene Symbol: cyb5r3    Nomenclature History

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Previous Names: fc32h03, wu:fc32h03, zgc:77071 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits NADH dehydrogenase activity. Involved in oxidation-reduction process. Is expressed in yolk syncytial layer. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3).
Genome Resources: Alliance (1),  Gene:324560 (1),  Ensembl(GRCz11):ENSDARG00000005891 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2005 [eu1002]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31384 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyb5r3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Methemoglobinemia, type I 250800
    Methemoglobinemia, type II 250800
    DISEASE ASSOCIATED WITH cyb5r3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Molecular Function NADH dehydrogenase activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyb5r3-201 (1)    Ensembl 1890
    cyb5r3-202 (1)    Ensembl 537
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyb5r3 No data available
    MARKER RELATIONSHIPS
    cyb5r3 Contained in: [BAC] CH211-161F1 (1)
    cyb5r3 Encodes: [EST] eu1002 (1), fc32h03
    [cDNA] MGC:77071 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212685 (1) 1930 nt
    Genomic GenBank:BX649350 (1) 115188 nt
    Select Tool
    Polypeptide UniProtKB:Q1MTC9 (1) 298 aa
    Sequence Information (all 15)
    ORTHOLOGY for cyb5r3 ( Chr: 4 )
    CITATIONS (28)