ZFIN ID: ZDB-GENE-030131-2965
Gene Name: leucine rich repeat containing 8 VRAC subunit C
Gene Symbol: lrrc8c    Nomenclature History

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Previous Names: fc22f12, wu:fc22f12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have volume-sensitive anion channel activity. Predicted to be involved in anion transmembrane transport. Predicted to localize to the cytoplasm and ion channel complex. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000099911 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010503Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20688 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26729 Point Mutation Unknown Premature Stop ENU
    sa40672 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lrrc8c HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lrrc8c VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component integral component of membrane (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR021040 LRRC8, pannexin-like TM region
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lrrc8c-201 (1)    Ensembl 2494
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrrc8c No data available
    MARKER RELATIONSHIPS
    lrrc8c Contained in: [BAC] CH73-97H19 (1), DKEY-238N5 (1) (order this)
    lrrc8c Encodes: [EST] fc22f12
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:AI658132 (1) 534 nt
    Genomic GenBank:CR790380 (1) 170914 nt
    Select Tool
    Polypeptide UniProtKB:E7F333 (1) 792 aa
    Sequence Information (all 5)
    ORTHOLOGY for lrrc8c ( Chr: 6 )
    CITATIONS (18)