ZFIN ID: ZDB-GENE-030131-2921
Gene Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Gene Symbol: dlat    Nomenclature History

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Previous Names: fc86g11, fj57d06, no optokinetic nystagmus a, no optokinetic response b (1), noa, nrb (1), wu:fc14f10 (1), wu:fc21f08 (1), wu:fc86g11 (1), wu:fj57d06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Contributes to pyruvate dehydrogenase activity. Involved in acetyl-CoA biosynthetic process from pyruvate and detection of light stimulus involved in visual perception. Predicted to localize to mitochondrial pyruvate dehydrogenase complex. Is expressed in several structures, including adaxial cell; ectoderm; head; immature eye; and pronephric duct. Used to study lactic acidosis and pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase).
Genome Resources: Alliance (1),  Gene:324201 (1),  Ensembl(GRCz11):ENSDARG00000015918 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a13 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m631 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37305 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37306 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH dlat HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pyruvate decarboxylase deficiency Alliance Pyruvate dehydrogenase E2 deficiency 245348
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
    Cellular Component pyruvate dehydrogenase complex (more)
    Molecular Function CONTRIBUTES_TO   pyruvate dehydrogenase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlat-201 (1)    Ensembl 3382
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlat No data available
    MARKER RELATIONSHIPS
    dlat Contained in: [BAC] CH73-285B21 (1), DKEYP-14B8 (1)
    dlat Contains: [SNP] rs3729104 (1), rs3729105 (1)
    dlat Encodes: [EST] fc14f10, fc21f08, fc86g11, fj57d06
    [cDNA] MGC:194568 (1), MGC:194582 (1)
    dlat Has Artifact: [cDNA] MGC:111854 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212667 (1) 1959 nt
    Genomic GenBank:BX296544 (1) 168838 nt
    Select Tool
    Polypeptide UniProtKB:B3DIV6 (1) 652 aa
    Sequence Information (all 22)
    ORTHOLOGY for dlat ( Chr: 21 )
    CITATIONS (38)