ZFIN ID: ZDB-GENE-030131-2887
Gene Name: polymerase (RNA) III (DNA directed) polypeptide B
Gene Symbol: polr3b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: slj, si:dkey-103i16.3, slim jim, wu:fc20h06

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in digestive tract development; exocrine pancreas development; and tRNA transcription. Predicted to localize to RNA polymerase III complex. Is expressed in intestine; liver; nervous system; and retina. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism. Orthologous to human POLR3B (RNA polymerase III subunit B).
Genome Resources: Alliance (1),  Gene:562329 (1),  Ensembl(GRCz11):ENSDARG00000062915 (1)
GENE EXPRESSION
All Expression Data: Fig. 4 from Yee et al., 2007
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m74 Point Mutation Acceptor Splice Site of Intron 10 Unknown ENU
sa23261 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43070 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-polr3b N/A 1
    MO2-polr3b N/A 1
    DISEASE ASSOCIATED WITH polr3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism Alliance Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism 614381
    DISEASE ASSOCIATED WITH polr3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive tract development (more)
    Cellular Component RNA polymerase III complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM polr3b No data available
    MARKER RELATIONSHIPS
    polr3b Contained in: [BAC] DKEY-103I16 (1) (order this)
    polr3b Encodes: [EST] fc20h06, tdsubs_rzpd609_26n13
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021467775 (1)
    Genomic GenBank:BX465207 (1) 265632 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QQA2 (1) 1130 aa
    Sequence Information (all 16)
    ORTHOLOGY for polr3b ( Chr: 18 )
    CITATIONS (29)