ZFIN ID: ZDB-GENE-030131-2862
Gene Name: ADAM metallopeptidase domain 17a
Gene Symbol: adam17a    Nomenclature History

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Previous Names: fc20b01, wu:fc20b01, zgc:63886

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
Genome Resources: Alliance (1),  Gene:324142 (1),  Ensembl(GRCz11):ENSDARG00000043213 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15007 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17758 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42975 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH adam17a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Inflammatory skin and bowel disease, neonatal, 1 614328
    DISEASE ASSOCIATED WITH adam17a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process integrin-mediated signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function metalloendopeptidase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adam17a-201 (1)    Ensembl 5410
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adam17a No data available
    MARKER RELATIONSHIPS
    adam17a Contained in: [BAC] DKEY-174C12 (1) (order this)
    adam17a Encodes: [EST] fc20b01
    [cDNA] MGC:63886 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199673 (1) 5431 nt
    Genomic GenBank:CR556709 (1) 73449 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q3V6 (1) 848 aa
    Sequence Information (all 14)
    ORTHOLOGY for adam17a ( Chr: 17 )
    CITATIONS (23)