ZFIN ID: ZDB-GENE-030131-2845
Gene Name: serine/threonine kinase 3 (STE20 homolog, yeast)
Gene Symbol: stk3    Nomenclature History

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Previous Names: mst2, wu:fc19e11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in camera-type eye development. Predicted to localize to the cytoplasm. Orthologous to several human genes including STK3 (serine/threonine kinase 3).
Genome Resources: Alliance (1),  Gene:324125 (1),  Ensembl(GRCz11):ENSDARG00000011312 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55383]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020769Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17740 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-stk3 N/A 1
    PHENOTYPE
    Data: Fig. 1 from Asaoka et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH stk3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH stk3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process camera-type eye development (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein kinase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR011524 SARAH domain
    Domain IPR024205 Mst1 SARAH domain
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA stk3-201 (1)    Ensembl 2895
    ncRNA stk3-002 (1) 585
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stk3 No data available
    MARKER RELATIONSHIPS
    stk3 Contained in: [BAC] DKEY-255N2 (1) (order this)
    stk3 Encodes: [EST] fc19e11
    [cDNA] MGC:55383 (1), MGC:191390 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199672 (1) 2943 nt
    Genomic GenBank:BX293540 (1) 181168 nt
    Select Tool
    Polypeptide UniProtKB:B2GP54 (1) 492 aa
    Sequence Information (all 15)
    ORTHOLOGY for stk3 ( Chr: 19 )
    CITATIONS (34)