ZFIN ID: ZDB-GENE-030131-283
Gene Name: eukaryotic translation initiation factor 2, subunit 1 alpha b
Gene Symbol: eif2s1b    Nomenclature History

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Previous Names: eif2s1, fb19d01, wu:fb19d01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have ribosome binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to localize to several cellular components, including eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 2 complex; and eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including immature eye; musculature system; nervous system; pharyngeal arch 3-7 skeleton; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha).
Genome Resources: Alliance (1),  Gene:321564 (1),  Ensembl(GRCz11):ENSDARG00000052178 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23820 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif2s1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH eif2s1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process translation (more)
    Cellular Component cytoplasm (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif2s1b-201 (1)    Ensembl 1345
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif2s1b No data available
    MARKER RELATIONSHIPS
    eif2s1b Contained in: [BAC] CH211-105D18 (1)
    eif2s1b Encodes: [EST] fb19d01 (order this)
    [cDNA] MGC:56347 (1), MGC:77851 (1), MGC:174442 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131800 (1) 1451 nt
    Genomic GenBank:AL928824 (1) 189742 nt
    Select Tool
    Polypeptide UniProtKB:Q9I9E9 (1) 315 aa
    Sequence Information (all 19)
    ORTHOLOGY for eif2s1b ( Chr: 20 )
    CITATIONS (29)