ZFIN ID: ZDB-GENE-030131-2826
Gene Name: TLE family member 2, transcriptional corepressor a
Gene Symbol: tle2a    Nomenclature History

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Previous Names: tle2 (1), fc18h03, sb:eu1034, sb:eu408, si:ch211-81i17.1, wu:fb96a10, wu:fc18h03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to localize to nucleus and transcription regulator complex. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor).
Genome Resources: Alliance (1),  Gene:565013 (1),  Ensembl(GRCz11):ENSDARG00000042484 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu825]
  1 figure (1 image) from Thisse et al., 2005 [eu856]
  1 figure (1 image) from Thisse et al., 2005 [eu408]
  1 figure (1 image) from Thisse et al., 2005 [eu1034]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9041 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12775 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tle2a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tle2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tle2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function repressing transcription factor binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tle2a-202 (1)    Ensembl 3739
    ncRNA tle2-002 (1)    Ensembl 597
    tle2-003 (1)    Ensembl 568
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tle2a No data available
    MARKER RELATIONSHIPS
    tle2a Contained in: [BAC] CH211-57N1 (1), CH211-81I17 (1), CH211-206A19 (1)
    tle2a Encodes: [EST] eu408 (1), eu825 (1), eu856 (1), eu1034 (1), fb96a10, fc18h03
    [cDNA] MGC:195218 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001130604 (1) 2759 nt
    Genomic GenBank:BX569795 (1) 162622 nt
    Select Tool
    Polypeptide UniProtKB:B3DJR5 (1) 811 aa
    Sequence Information (all 37)
    ORTHOLOGY for tle2a ( Chr: 22 )
    CITATIONS (23)