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ZIRC
ZFIN ID: ZDB-GENE-030131-2743
Gene Name: desmoplakin a
Gene Symbol: dspa    Nomenclature History

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Previous Names: im:6911953, sb:cb570, wu:fc17a08, wu:fk73d01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Predicted to be involved in several processes, including intermediate filament cytoskeleton organization; skin development; and wound healing. Predicted to colocalize with the intermediate filament. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Is expressed in several structures, including EVL; digestive system; ectoderm; epidermis; and pectoral fin. Orthologous to human DSP (desmoplakin).
Genome Resources: Alliance (1),  Gene:324023 (1),  Ensembl(GRCz11):ENSDARG00000022309 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028747Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa302 Point Mutation Unknown Premature Stop ENU
    sa13356 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19650 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19651 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30809 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38306 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39744 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dspa N/A 1
    MO2-dspa N/A 1
    DISEASE ASSOCIATED WITH dspa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arrhythmogenic right ventricular dysplasia 8 Alliance Arrhythmogenic right ventricular dysplasia 8 607450
    Carvajal syndrome Alliance Cardiomyopathy, dilated, with woolly hair and keratoderma 605676
    Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis 615821
    Epidermolysis bullosa, lethal acantholytic 609638
    Keratosis palmoplantaris striata II 612908
    Skin fragility-woolly hair syndrome 607655
    DISEASE ASSOCIATED WITH dspa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component cell junction (more)
    Molecular Function cell adhesion molecule binding (more)
    GO Terms (all 13)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dspa-201 (1)    Ensembl 7020
    ncRNA dspa-002 (1) 1221
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dspa No data available
    MARKER RELATIONSHIPS
    dspa Contained in: [BAC] CH73-264D1 (1) (order this), CH73-325J23 (1) (order this), CH211-163F10 (1) (order this)
    [Fosmid] CH1073-208A8 (1) (order this)
    dspa Contains: [SNP] rs3727584 (1)
    dspa Encodes: [EST] cb570 (1) (order this), fc17a08, fk73d01, IMAGE:6911953 (1) (order this), fb65a04 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001919866 (1) 8177 bp
    Genomic GenBank:AL929518 (1) 162473 bp
    Select Tool
    Polypeptide UniProtKB:F8W4Q1 (1) 2059 aa
    Sequence Clusters UniGene:156342 (1)
    Sequence Information (all 35)
    ORTHOLOGY for dspa ( Chr: 2 )
    CITATIONS (28)