ZFIN ID: ZDB-GENE-030131-2721
Gene Name: adducin 3 (gamma) a
Gene Symbol: add3a    Nomenclature History

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Previous Names: add3, wu:fb38g03, wu:fc16e06, zgc:55560, zgc:77226

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Involved in hepaticobiliary system development. Predicted to localize to the cytoskeleton; plasma membrane raft; and postsynaptic density. Used to study biliary atresia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Is expressed in head; liver; pericardial region; and pleuroperitoneal region. Orthologous to human ADD3 (adducin 3).
Genome Resources: Alliance (1),  Gene:556762 (1),  Ensembl(GRCz11):ENSDARG00000040874 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022313Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa819 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11284 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11322 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19300 Point Mutation Unknown Premature Stop ENU
    sa37547 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37548 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-add3a N/A 1
    MO2-add3a N/A 1
    MO3-add3a N/A 1
    DISEASE ASSOCIATED WITH add3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cerebral palsy, spastic quadriplegic, 3 617008
    DISEASE ASSOCIATED WITH add3a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    biliary atresia add3asa819/sa819 standard conditions Tang et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hepaticobiliary system development (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001303 Class II aldolase/adducin N-terminal
    Family IPR027772 Gamma-adducin
    Homologous_superfamily IPR036409 Class II aldolase/adducin N-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA add3a-202 (1)    Ensembl 3671
    add3a-203 (1)    Ensembl 3494
    add3a-205 (1)    Ensembl 871
    add3a-206 (1)    Ensembl 612
    add3a-207 (1)    Ensembl 570
    ncRNA add3a-005 (1) 849
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM add3a No data available
    MARKER RELATIONSHIPS
    add3a Contained in: [BAC] CH211-196C2 (1), DKEY-234D4 (1) (order this), DKEY-286J15 (1) (order this)
    add3a Encodes: [EST] fb38g03, fc16e06
    [cDNA] MGC:55560 (1), MGC:55992 (1), MGC:77226 (1), MGC:192731 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199663 (1) 2898 nt
    Genomic GenBank:AL845330 (1) 175991 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q5P5 (1) 678 aa
    Sequence Information (all 61)
    ORTHOLOGY for add3a ( Chr: 22 )
    CITATIONS (33)