ZFIN ID: ZDB-GENE-030131-271
Gene Name: slow myosin heavy chain 1
Gene Symbol: smyhc1    Nomenclature History

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Previous Names: smhc1 (1), fb18g10, im:6897999, wu:fb18g10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in skeletal muscle thin filament assembly; slow-twitch skeletal muscle fiber contraction; and striated muscle myosin thick filament assembly. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Is expressed in cardiovascular system; musculature system; paraxial mesoderm; and somite. Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
Genome Resources: Alliance (1),  Gene:321552 (1),  Ensembl(GRCz11):ENSDARG00000099959 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12384 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24569 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30154 Point Mutation Unknown Premature Stop ENU
    sa30155 Point Mutation Unknown Splice Site ENU
    sa30156 Point Mutation Unknown Premature Stop ENU
    sa37966 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45841 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-smyhc
    1
    CRISPR1-smyhc1
    2
    CRISPR2-smyhc
    1
    CRISPR4-smyhc1
    2
    MO1-smyhc1 N/A 2
    MO2-smyhc1 N/A 2
    DISEASE ASSOCIATED WITH smyhc1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smyhc1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process slow-twitch skeletal muscle fiber contraction (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smyhc1-201 (1)    Ensembl 6575
    ncRNA cu633479.5-201 (1)    Ensembl 700
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smyhc1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(smyhc1:EGFP) smyhc1 EGFP Danio rerio 5 21
    Tg(smyhc1:GCaMP3) smyhc1 GCaMP Danio rerio 1 3
    tg(smyhc1:lox2272-loxp-tomato-lox2272-cerulean-loxp-eyfp) smyhc1 CeruleanEYFPLOX2272LOXPTomato Danio rerio 1 1
    Tg(smyhc1:LY-Tomato) smyhc1 Tomato Danio rerio 2 4
    Tg(smyhc1:mCherry-CAAX) smyhc1 mCherry Danio rerio 1 3
    Tg(smyhc1:musk-002-MYC) smyhc1 musk Danio rerio 1 2
    Tg(smyhc1:musk-003-MYC) smyhc1 musk Danio rerio 1 3
    Tg(smyhc1:MYC-plod3) smyhc1 plod3 Danio rerio 1 4
    Tg2(smyhc1:EGFP) smyhc1 EGFP Danio rerio 1 2
    TgBAC(smyhc1:EGFP) smyhc1 EGFP Danio rerio 1 7
    MARKER RELATIONSHIPS
    smyhc1 Contained in: [BAC] CH211-24N20 (1)
    smyhc1 Encodes: [EST] fb18g10 (order this), IMAGE:6897999 (1)
    [cDNA] MGC:194801 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020507 (1) 5905 bp
    Genomic GenBank:CU929259 (1) 195306 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q7G9 (1) 1969 aa
    Sequence Information (all 34)
    ORTHOLOGY for smyhc1 ( Chr: 24 )
    CITATIONS (106)