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General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-264
Gene Name: serpin peptidase inhibitor, clade C (antithrombin), member 1
Gene Symbol: serpinc1
Sequence Ontology ID : SO:0001217

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Attributions

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Previous Names: at3 (1), ATIII (1), antithrombin III (1), wu:fb18f10, zgc:92299

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have serine-type endopeptidase inhibitor activity. Involved in cellular response to estrogen stimulus and regulation of blood coagulation. Predicted to localize to the extracellular  ...
GENE EXPRESSION
All Expression Data: 25 figures from 6 publications
Directly Submitted Expression Data: 12 figures (6 images) from Rauch et al., 2003 [fb18f10]
  7 figures (10 images) from Thisse et al., 2005 [eu1051]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zf548 Small Deletion Exon 5 Unknown ZINC_FINGER_NUCLEASE
zf549 Small Deletion Exon 5 Unknown ZINC_FINGER_NUCLEASE
DISEASE ASSOCIATED WITH serpinc1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
antithrombin III deficiency Thrombophilia due to antithrombin III deficiency 613118
DISEASE ASSOCIATED WITH serpinc1 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
disseminated intravascular coagulation serpinc1zf548/zf548 standard conditions Liu et al., 2014
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular response to estrogen stimulus (more)
Cellular Component extracellular space (more)
Molecular Function heparin binding (more)
GO Terms (all 7)
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA serpinc1-201 (1) 2424
GENE PRODUCT DESCRIPTION
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM serpinc1 No data available
MARKER RELATIONSHIPS
serpinc1 Contained in: [BAC] DKEY-192M14 (1) (order this)
serpinc1 Contains: [SNP] rs3729172 (1), rs3729173 (1), rs3729174 (1), rs3729175 (1), rs3729176 (1), rs3729177 (1), rs3729178 (1)
serpinc1 Encodes: [EST] eu1051 (1), fb18f10 (order this)
[cDNA] MGC:92299 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_182863 (1) 2427 bp
Genomic GenBank:BX908392 (1) 179577 bp
Select Tool
Polypeptide UniProtKB:Q8AYE3 (1) 450 aa
Sequence Clusters UniGene:4199 (1)
Sequence Information (all 17)
ORTHOLOGY for serpinc1 ( Chr: 22 )
CITATIONS (33)