ZFIN ID: ZDB-GENE-030131-2581
Gene Name: Wolf-Hirschhorn syndrome candidate 1
Gene Symbol: whsc1
Previous Names: fc12c04, si:rp71-77d7.2, wu:fc12c04, wu:fi20c01
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [IMAGE:7158283]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, central nervous system, eye, fin (all 16) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: whsc1scu1/scu1
Knockdown reagents: CRISPR1-whsc1 (1), MO1-whsc1 (1), MO2-whsc1 (1), MO3-whsc1 (1)

Allele Type Mutagen Suppliers
scu1 Indel CRISPR
PHENOTYPE
Data: 4 figures from Yamada-Okabe et al., 2010
Observed in: bone development, brain, cartilage element, ceratobranchial cartilage (all 10) expand
DISEASE ASSOCIATED WITH whsc1 HUMAN ORTHOLOG No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cartilage development (more)
Cellular Component nucleus (more)
Molecular Function histone-lysine N-methyltransferase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000313 (1)
  • InterPro:IPR001214 (1)
  • InterPro:IPR001841 (1)
  • InterPro:IPR001965 (1)
  • InterPro:IPR003616 (1)
  • InterPro:IPR006560 (1)
  • InterPro:IPR011011 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR019786 (1)
  • InterPro:IPR019787 (1)
  • PROSITE:PS01359 (1)
  • PROSITE:PS50016 (1)
  • PROSITE:PS50280 (1)
  • PROSITE:PS50812 (1)
  • PROSITE:PS50868 (1)
  • PROSITE:PS51215 (1)
  • Pfam:PF00628 (1)
  • Pfam:PF00855 (1)
  • Pfam:PF00856 (1)
  • EC:2.1.1.43 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA whsc1-001 (1) 5357
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM whsc1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    whsc1 Contained in: [BAC] CH211-195N12 (1) (order this), CH211-233A24 (1) (order this)
    whsc1 Encodes: [EST] fc12c04, fi20c01, IMAGE:7158283 (1) (order this)
    [cDNA] MGC:198423 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001082551 (1) 5347 bp
    Genomic GenBank:CR556722 (1) 205873 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B7ZVT1 (1) 1461 aa
    Sequence Clusters UniGene:78031 (1)
    Sequence Information (all 44)
    OTHER whsc1 GENE PAGES
  • Gene:100000709 (1)
  • VEGA:OTTDARG00000023818 (1)
  • Ensembl(Zv9):ENSDARG00000026225 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish whsc1 13  
    Human WHSC1 4 (4p16.3)
  • OMIM:602952
  • Gene:7468
  • Mouse Whsc1 5 ( 17.83 cM)
  • MGI:1276574
  • Gene:107823
  • Orthology Details
    CITATIONS (20)