Gene

nsd2

ID
ZDB-GENE-030131-2581
Name
nuclear receptor binding SET domain protein 2
Symbol
nsd2 Nomenclature History
Previous Names
  • fc12c04
  • si:rp71-77d7.2
  • whsc1
  • wu:fc12c04
  • wu:fi20c01
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable histone methyltransferase activity (H3-K36 specific). Acts upstream of or within cartilage development; embryonic skeletal system development; and histone H3-K36 dimethylation. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including fin; immature eye; nervous system; neural plate; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nsd2 Human Ortholog
No data available
Associated With nsd2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019786 Zinc finger, PHD-type, conserved site
Domain IPR000313 PWWP domain
Domain IPR001214 SET domain
Domain IPR001965 Zinc finger, PHD-type
Domain IPR003616 Post-SET domain
Domain IPR006560 AWS domain
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR041306 NSD, Cys-His rich domain
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain Details Per Protein
Protein Length AWS domain NSD, Cys-His rich domain Post-SET domain PWWP domain SET domain Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, PHD-type, conserved site Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A2R8Q4N9 1459
UniProtKB:Q1LY48 728
UniProtKB:B7ZVT1 1461
UniProtKB:A0A2R8Q9Y9 598
UniProtKB:A9JT62 508
UniProtKB:B8JIA4 1461
UniProtKB:Q5EB10 569
UniProtKB:A5XBQ1 130
UniProtKB:A7YT41 486
UniProtKB:Q06ZW5 1366
UniProtKB:Q1LY49 605
UniProtKB:A4QP02 554
UniProtKB:Q561Q3 320
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations