ZFIN ID: ZDB-GENE-030131-2415
Gene Name: caveolin 1
Gene Symbol: cav1    Nomenclature History

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Previous Name: wu:fc07c04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits beta-catenin binding activity. Involved in several processes, including animal organ development; regionalization; and regulation of defense response. Predicted to colocalize with caveola; focal adhesion; and sarcolemma. Is expressed in several structures, including cardiovascular system; ectoderm; integument; lateral line system; and tail bud. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1).
Genome Resources: Alliance (1),  Gene:323695 (1),  Ensembl(GRCz11):ENSDARG00000103747 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014687Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pd1094 Small Deletion Unknown Unknown TALEN
    pd1104 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cav1
    2
    CRISPR2-cav1
    2
    CRISPR3-cav1
    1
    CRISPR4-cav1
    1
    MO1-cav1 N/A 4
    MO2-cav1 N/A 2
    MO3-cav1 N/A 1
    MO4-cav1 N/A 1
    MO5-cav1 N/A 1
    MO6-cav1 N/A 1
    TALEN1-cav1 1
    TALEN2-cav1 1
    DISEASE ASSOCIATED WITH cav1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital generalized lipodystrophy type 3 Alliance ?Lipodystrophy, congenital generalized, type 3 612526
    primary pulmonary hypertension Alliance Pulmonary hypertension, primary, 3 615343
    Lipodystrophy, familial partial, type 7 606721
    DISEASE ASSOCIATED WITH cav1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intestinal cholesterol absorption (more)
    Cellular Component caveola (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cav1-201 (1)    Ensembl 3830
    cav1-202 (1)    Ensembl 1582
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cav1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:cav1-EGFP) hsp70l cav1EGFP Danio rerio 3 1
    Tg(UAS:cav1,myl7:EGFP) myl7UAS cav1EGFP Danio rerio 1 1
    Tg2(UAS:cav1,myl7:EGFP) myl7UAS cav1EGFP Danio rerio 1 1
    TgBAC(cav1:cav1-EGFP) cav1 cav1EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    cav1 Contained in: [BAC] CH211-226K23 (1)
    cav1 Encodes: [EST] fc07c04, IMAGE:6911989 (1)
    [cDNA] MGC:136627 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212651 (1) 1748 nt
    Genomic GenBank:CR848711 (1) 187021 nt
    Select Tool
    Polypeptide UniProtKB:Q6YLH9 (1) 181 aa
    Sequence Information (all 24)
    ORTHOLOGY for cav1 ( Chr: 25 )
    CITATIONS (58)