ZFIN ID: ZDB-GENE-030131-2411
Gene Name: host cell factor C1b
Gene Symbol: hcfc1b    Nomenclature History

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Previous Names: fc07b09, fe17f08, wu:fc07b09, wu:fe17f08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have chromatin binding activity and transcription factor binding activity. Involved in chondrocyte differentiation and embryonic viscerocranium morphogenesis. Predicted to localize to Ada2/Gcn5/Ada3 transcription activator complex. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Orthologous to human HCFC1 (host cell factor C1).
Genome Resources: Alliance (1),  Gene:565206 (1),  Ensembl(GRCz11):ENSDARG00000012519 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010756Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la016453Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7624 Point Mutation Unknown Missense ENU
    sa34295 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38666 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38667 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hcfc1b N/A 2
    DISEASE ASSOCIATED WITH hcfc1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    methylmalonic acidemia and homocysteinemia cblX type Alliance Mental retardation, X-linked 3 (methylmalonic acidemia and homocysteinemia, cblX type ) 309541
    DISEASE ASSOCIATED WITH hcfc1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chondrocyte differentiation (more)
    Cellular Component MLL1 complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hcfc1b-201 (1)    Ensembl 7799
    ncRNA hcfc1b-002 (1)    Ensembl 776
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hcfc1b No data available
    MARKER RELATIONSHIPS
    hcfc1b Contained in: [BAC] DKEYP-77F7 (1)
    hcfc1b Encodes: [EST] fc07b09, fe17f08
    hcfc1b Has Artifact: [EST] fe25f02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128537 (1) 7799 nt
    Genomic GenBank:BX571687 (1) 173448 nt
    Select Tool
    Polypeptide UniProtKB:A8WIP5 (1) 1993 aa
    Sequence Information (all 19)
    ORTHOLOGY for hcfc1b ( Chr: 8 )
    CITATIONS (24)