ZFIN ID: ZDB-GENE-030131-2352
Gene Name: integral membrane protein 2Ba
Gene Symbol: itm2ba    Nomenclature History

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Previous Names: itm2b, wu:fc05f02, zgc:55770, zgc:85688

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have amyloid-beta binding activity. Predicted to be involved in negative regulation of amyloid precursor protein biosynthetic process. Predicted to localize to Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in ITM2B-related cerebral amyloid angiopathy 1 and ITM2B-related cerebral amyloid angiopathy 2. Orthologous to human ITM2B (integral membrane protein 2B).
Genome Resources: Alliance (1),  Gene:323632 (1),  Ensembl(GRCz11):ENSDARG00000007098 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:85688]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10613 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH itm2ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ITM2B-related cerebral amyloid angiopathy 1 Alliance Dementia, familial British 176500
    ITM2B-related cerebral amyloid angiopathy 2 Alliance Dementia, familial Danish 117300
    ?Retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities 616079
    DISEASE ASSOCIATED WITH itm2ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of amyloid precursor protein biosynthetic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function amyloid-beta binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itm2ba-201 (1)    Ensembl 1859
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itm2ba No data available
    MARKER RELATIONSHIPS
    itm2ba Contained in: [BAC] CH73-374O20 (1)
    itm2ba Encodes: [EST] fc05f02, wz5884
    [cDNA] MGC:55770 (1), MGC:85688 (1), MGC:158227 (1), MGC:191769 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199646 (1) 1841 nt
    Genomic GenBank:CU929158 (1) 89705 nt
    Select Tool
    Polypeptide UniProtKB:Q6NV09 (1) 261 aa
    Sequence Information (all 23)
    ORTHOLOGY for itm2ba ( Chr: 6 )
    CITATIONS (21)